Comparison of analgesic and functional outcomes of Intra-articular Ketorolac versus Triamcinolone Acetone Injection in Patients of Knee Osteoarthritis.

Gondal, Soban Sarwar; Zareen, Abeera; Anwar, Muhammad Haroon; Zaheer, Jawad; Salim, Muhammad

Objective: To compare the analgesic and functional outcomes of intra-articular ketorolac with corticosteroids in patients of knee osteoarthritis (OA). Materials and Methods: In this randomized double-blind comparative study, we included patients of knee OA who were planned for intra-articular injections from January-2020 to December-2020 in the Department of Anesthesia and Pain Medicine at Rawalpindi Medical University. Patients having symptomatic knee OA of Kellgren-Lawrence grades 2 or 3 and age 40-70 years were allocated to two groups using block randomization, each block contained 30 patients and received an injection of either triamcinolone (Group T) or ketorolac (Group K). VAS score and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score were noted at 1 week, 1 month, and at 3 months of injection. Results: Mean baseline WOMAC score was 46.60±5.64 in group K and 47.0±5.27 in group T (p-value 0.74). Mean WOMAC score was reduced significantly at 1st week and 1 month and 3 months follow-up in both groups, with an insignificant statistical difference in group K and T (p-value 0.39, 0.18 & 0.15 respectively). The baseline VAS score was 7.02±1.34 in group K versus 7.27±1.03 in group T (p-value 0.36). VAS score was also reduced at 1 week, 1 month, and 3 months follow-up, however the mean VAS at intervals was not statistically different between group K and T with a p-value of 0.13, 0.08, and 0.49 respectively. Treatment was successful in 22 (55%) patients in group K versus 24 (60%) patients in group T (p-value 0.65). Conclusion: Intraarticular ketorolac has similar functional and analgesic outcomes as that of triamcinolone.

KNEE osteoarthritis; TRIAMCINOLONE; INTRA-articular injections; FUNCTIONAL status; KETOROLAC

Journal of Rawalpindi Medical College, 2021, Vol 25, Issue 4, p512

1683-3562

Academic Journal

10.37939/jrmc.v25i4.1750