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- Title
Atypical juvenile myoclonic epilepsy with structural brain abnormalities and cognitive impairment: A case report.
- Authors
Sari, Putri Permata; Gunawan, Prastiya Indra; Noviandi, Riza; Samosir, Sunny Mariana
- Abstract
Juvenile myoclonic epilepsy (JME) is an idiopathic generalized epilepsy affecting 5–10% of epilepsy patients. Its exact cause remains unknown, but recent studies indicate frontal region involvement. It responds well to anticonvulsants but is often misdiagnosed with focal-onset epilepsy. We present a 9-year-old girl with myoclonic, absence, and generalized tonic-clonic seizures happening over three months. EEG revealed slow spike and wave complexes with generalized polyspikes, while brain MRI identified encephalomalacia cysts with right frontotemporal lobe hemiatrophy. Valproic acid treatment led to seizure-free status for one month. In conclusion, timely EEG and neuroimaging are pivotal in identifying structural abnormalities in JME patients with pronounced cognitive impairment, enabling tailored treatment and better outcomes.
- Subjects
EPILEPSY; BRAIN abnormalities; COGNITION disorders; VALPROIC acid; SEIZURES (Medicine); PEOPLE with epilepsy
- Publication
Romanian Journal of Neurology, 2023, Vol 22, Issue 3, p265
- ISSN
1843-8148
- Publication type
Academic Journal
- DOI
10.37897/RJN.2023.3.15