Immunological role of TLR-7, IL-17A and IL-10 In a Sample of Iraqi Chronic Renal Failure Patients.

Shyeaa, Asaal Abdul-Ghani; Saleh, Mohammed Abdul-Daim; Tektook, Nihad Khalawe

Objectives: The present study designed to investigate the Immunological role of toll-like receptor-7,IL-17A and IL-10 in sera of 66 Chronic Renal Failure CRF patients at IBN-SINA center for Dialysis in Diyala governorate - Iraq.Methods: Sandwich Enzyme Linked Immuno-Sorbent Assay(ELISA) technique were used in this study to evaluate concentration of TLR-7,IL-17A and IL-10 between study groups.Results: The findings of the present study demonstrated that significantly increased level of TLR-7 in the CRF group (0.24±0.05 ng/ml) compared to controls (0.02 ±0.08 ng/ml), the findings revealed a significant association between CRF and IL-17A serum level in the studied groups,There was a significantly increased level of IL-17A in the CRF group (6.50±1.37 pg/ml) compared to controls (2.19±0.32 pg/ml) also decreased level of IL-10 in the CRF group (26.20 ±5.16 pg/ml) compared to controls (79.27±23.44 pg/ml).Conclusion: These findings concluded that TLR-7, IL-17A and IL-10 might have a role in CRF pathogenesis.

IRAQ; INTERLEUKINS; CHRONIC kidney failure; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; TOLL-like receptors

Medico-Legal Update, 2020, Vol 20, Issue 1, p1446

0971-720X

Academic Journal

10.37506/v20/i1/2020/mlu/194506