Serum Citrin and γ-Glutamyl Transferase as Biomarkers for Infantile Cholestasis Severity.

Al-Bassam, Mostafa; AL-Saeed, Hassan H.; Arif, Hala Sameh

One of the most important parameters to evaluate severity and type of cholestasis disease is gamma-glutamyl transferase and citrin protein measurements. The objective of this study was to assess the clinical value of serum citrin protein with gamma-glutamyl transferase in children with cholestasis.60 subjects with diseases and 25 healthy subjects distributed intothree groups, citrinand gamma-glutamyl transferasewere measured for all case and control studies by enzyme linked immunosorbent Assay. The results showed serum citrin has a highly significantly decreased in an intra- and extrahepatic cholestasis groups when compared with control (P<0.001), serum gamma-glutamyl transferasehas a highly significantly elevated in an intrahepatic cholestasis group when compared with control (P<0.003). From these findings it was concluded that serum gamma-glutamyl transferase level is a good marker in determining the severity of cholestasis disease, serum citrin may be useful in future to diagnose the cholestasis caused by citrin deficiency.

CHOLESTASIS; BLOOD proteins; SERUM; BIOMARKERS

Indian Journal of Public Health Research & Development, 2020, Vol 11, Issue 2, p2422

0976-0245

Academic Journal

10.37506/v11/i2/2020/ijphrd/195200