GDM Common medical complication of pregnancy, it’s increasing enormously worldwide in the recent decades especially in developing countries, the onset of GDM occurred, due to islet β cell function defect .There are a close relationship between the GDM,OS, antioxidants and inflammation .The aim of this study was the assessment to oxidative stress factor changes, UA and CRP in pregnants women with GDM in misan province . The study included (30) GDM pregnant women, (25 -35) years. The study has during Nov.2018 to Feb. 2019 . Diagnosed parameters done by ELISA, and mindray (BS -230) .Our results reveledall parameters increased during pregnancy, highest increase in the third trimesters, it is increased significantly (p ≤0.05) in comparison with the first and second trimesters.