A 7-month-old, previously healthy Indonesian baby was referred with chief complaint of several general seizures, fever and diarrhea. The baby was irritable with positive pathological reflexes. Head CT scan suggesting meningoencephalitis. CSF culture resulted Salmonella spp and biochemical test supported Salmonella paratyphi B. The baby was treated with ampicillin and chloramphenicol for two weeks. The patient was discharge without neurological complication. Salmonella paratyphi B in infant is a rare entity and it is the first case that ever reported in Indonesia. Proper management with adequate antibiotics resulted satisfactory outcome.