Correlated between Sera Levels of Interleukins( IL-6, IL-17 and IL-23 ) with Virulence Genes Detected in Carbapenem-Resistant E.coli.

Mohammed Al-Warmeziary, Mehsen A.; Hussain, Suzan Saadi; Tektook, Nihad Khalawe

Current study demonstrated that 14.58% of isolated E. coli which positive for each of Omp -A, IMP- A, NDM- A and Fim- H genes were resistant to carbapenem and the study showed that 30.51% of E. coliisolates with KPC were resistant to carbapenem while other E. coli isolates with negative all genes were resistant to carbapenem, so the Percentage as 72.92% of isolated E. coli werepositive for each of Omp – A, IMP – A, NDM- A and Fim – H genes were occurred in females compared with 27.02% occurred in males and 40% of isolated E. coli with positive for KPC gene were in females with UTI. as well as 10, 50% of isolated E. coli werepositive for each of Omp- A, IMP - A, NDM- A and Fim - H genes were occurred in the age group 15-24 year and no isolate were form patients above 54 year.the highest mean levels IL-6 and IL-17 was recorded in UTI patients infected with E. coli positive for each of Omp- A, IMP- A, NDM- A and Fim- H comparing with patients infected with E. coli negative to these genes. Conclusion Carbapenem-resistant E. coli correlated with founded each of genes ( Omp -A, IMP- A, NDM- A and Fim- H ), whilst highest correlated between Carbapenem-resistant E. coli with KPC.so sera levels of both interleukins (IL-6 and IL-17) were recorded in UTI patients infected with E. coli positive for each genes ( Omp- A, IMP- A, NDM- A and Fim- H ) comparing with patients infected with E. coli negative to these genes.

INTERLEUKINS; INTERLEUKIN-6; GENES; SERUM; AGE groups

Indian Journal of Forensic Medicine & Toxicology, 2020, Vol 14, Issue 2, p2485

0973-9122

Academic Journal

10.37506/ijfmt.v14i2.3479