To compare survival outcomes in preoperative versus postoperative chemoradiation in stage III rectal cancer.

Kumar, Ramashish; Chauhan, Ashok K.; B. K., Raghavendra; Sharma, Deepak; Chandra, Varun; U., Yuvaraj; Dandagi, Veeresh

Background: Management of locally advanced rectal cancer requires a multidisciplinary strategy involving surgical resection with total mesorectal excision and combined use of radiotherapy and chemotherapy. Aim and Objective: To compare survival outcomes in Preoperative versus postoperative chemoradiation in Stage III Rectal cancer. Material and Methods: Fifty two patients of rectal cancer who received preoperative CRT (25 patients) or postoperative CRT (27 patients) of previously untreated stage III rectal cancer were analyzed retrospectively. All patients were treated at the department of Radiation Oncology, Pt B D Sharma PGIMS Rohtak between 2012 and 2018. Results: The median locoregional recurrence free survival in the preoperative group was 33 months whereas it was 32 months in the postoperative group (p=0.585). The median distant metastases free survival was 17 months in the preoperative group versus 35 months in the postoperative group (p=0.039). The mean survival in the preoperative group was 33.927 months versus 49.519 months in the postoperative radiotherapy group (p=0.129). Sphincter preservation rate of 51% in the preoperative CRT group. Conclusion: The present study concludes that there are no statistically significant differences in mean survival and median locoregional recurrence-free survival between the two groups. However, contrary to current literature, our findings show that the postoperative chemoradiation group had significantly better median distant metastasis-free survival. These results warrant further investigation through larger randomized studies.

RECTAL cancer; SURVIVAL rate; SURGICAL excision; CANCER patients; CHEMORADIOTHERAPY

Pravara Medical Review, 2024, Vol 16, Issue 3, p48

0975-0533

Academic Journal

10.36848/PMR/2024/90000.90052