In the present study conducted in Kanchipuram, Tamil Nadu, India, signifiicant fiindings emerged regarding antibiotic residues and antibiotic-resistant bacterial pathogens in chicken and goat meat from commercial vendors. The microbial analysis of 120 meat samples collected from 20 different shops revealed the widespread presence of various bacterial pathogens, with notable prevalence of Staphylococcus spp. and E. coli in both meat types. Notably, Salmonella spp. was more prevalent in chicken meat, highlighting the importance of stringent food safety measures in poultry products. In the realm of antibiotic susceptibility, Gram-negative pathogens exhibited variable resistance to different antibiotics, with ampicillin and penicillin showing high resistance rates, while imipenem demonstrated exceptional sensitivity. Among Gram-positive pathogens, linezolid and oxacillin proved highly effective, but ampicillin and penicillin faced signifiicant resistance. Importantly, the Minimum Inhibitory Concentration (MIC) tests underscored antibiotic resistance issues among both Gram-positive and Gram-negative pathogens. These fiindings accentuate the need for judicious antibiotic use in meat production and the urgency for further research to counter antibioticresistant bacterial infections effectively. This research contributes signifiicantly to our understanding of the complex interplay between antibiotic residues, antibiotic resistance, and meat product safety, offering critical insights for informed decision-making, healthcare practices, and potential policy interventions to ensure safer meat production and mitigate the global challenge of antibiotic resistance.