Results
Title

Association between vitamin D levels and overall survival, disease-free survival, and recurrence in gastric cancer patients.

Authors

Jayaraj, Abinaya; Naidu, Gopalakrishnan Thambu; Natarajan, Muninathan; Y., Lakshmi Archana

Abstract

Gastric cancer remains a significant global health burden despite advancements in treatment. Vitamin D, a well-known immunomodulator, has shown potential benefits in various cancers. This study aims to evaluate the association between vitamin D levels and clinical outcomes in gastric cancer patients. We will conduct a comprehensive search of electronic databases (PubMed, Embase, and Cochrane Library) to identify relevant studies. Included studies will assess the relationship between pre-operative or baseline vitamin D levels (measured as 25-hydroxyvitamin D) and overall survival, disease-free survival, and recurrence in gastric cancer patients. Pooled hazard ratios and corresponding confidence intervals will be calculated using meta-analysis techniques. Subgroup analyses will explore potential effect modifiers, such as age, sex, tumor stage, and geographic region. This review will provide robust evidence on the prognostic role of vitamin D in gastric cancer, informing clinical practice and guiding future research on vitamin D supplementation strategies.

Subjects

VITAMIN D; CANCER prognosis; CANCER relapse; PROGRESSION-free survival; DIETARY supplements

Publication

Pravara Medical Review, 2024, Vol 16, Issue 4, p19

ISSN

0975-0533

Publication type

Academic Journal

DOI

10.36848/PMR/2024/00000.10115