Aim and objectives: To determine the correlation of red cell distribution width (RDW) and mean platelet volume (MPV) in PIH patients in their third trimester. Materials and methods: The Study was carried out in Department of Physiology in collaboration with Department of Obstetrics and Gynecology, Dr. BVP Rural Medical College, Loni. Total of 152 subjects were studied. 82 healthy pregnant women (control group) and 70 PIH patients (case group). PIH patients were diagnosed cases by the department of Obstetrics and gynecology. Laboratory findings i.e. red blood cells distribution width (RDW) and mean platelet volume (MPV) of the given patients and control was noted. Results: The present study shows increase in RDW and MPV in preeclampsia women as compared to the control. There is a significant difference in RDW in severe preeclampsia patient and control with P-value <0.05. MPV is also significant in cases and control. Conclusion: The present study shows an increase in RDW and MPV in preeclampsia as compared to healthy pregnant women. The RDW and MPV can be used as prognostic markers as it is easily accessible and that do not imply an additional expense and can thus improve decision-making in patients with pre-eclampsia.