Results
Title

Comparative study of hypoglycaemic and antioxidant potential of methanolic seed extract and oil of Nigella sativa on alloxanized diabetic rabbits.

Authors

Akhtar, Muhammad Tahir; Ilyas, Hafiz Faisal; Shaukat, Usman Ali; Qadir, Rahman; Masood, Sahrish; Batool, Sajida; Zahoor, Sadaf; Saadia, Mubshara

Abstract

The present study was aimed to investigate the comparative antidiabetic potential of Nigella sativa seed extract and oil in an in vivo trial using rat animal model. The levels of antioxidants analysed in this study included catalase, vitamin C and bilirubin. NS methanolic extract and its oil were tested for their hypoglycemic effect against alloxanized diabetic rabbits (120mg/kg). The crude methanolic extract and the oil (2.5ml/kg/day) were given orally for 24 days that resulted in a significant reduction in glycaemia, particularly during the first 12 days of treatment (reductions of 58.09% and 73.27%, respectively), whereas the oil treated group normalised the levels of catalase (-69.23%), vitamin C (27.30%), and bilirubin (-51.48%) and the extract treated group normalised the levels of catalase (-65.38), vitamin C (24.15%), and bilirubin (-26.19%) at the end of the trial. The results have shown that the seed oil more significantly normalized the levels of serum catalase, serum ascorbic acid, and total serum bilirubin as compared to the methanolic extract of Nigella sativa, so Nigella sativa seed oil (NSO) may be used as part of antidiabetic remedies against diabetes and utilized as a nutraceutical.

Subjects

BLACK cumin; OILSEEDS; VITAMIN C; RABBITS; COMPARATIVE studies; LINSEED oil

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, p1755

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.SP.1755-1760.1