Results
Title

Evaluation of Anti-clotting and thrombolytic potential of the aqueousmethanolic extract of Jasminum sambac.

Authors

Gul-E-Mizgan; Kousar, Saba; Khan, Imran Ahmad; Perwasha, Perwasha; Gul, Humaira; Aslam, Iqra; Abbas, Ameen; Qurat-ul-Ain

Abstract

This study was done to investigate the anti-clotting and thrombolytic potential of ariel part of Jasminum sambac (L.). Healthy male rabbits were divided into five (5) groups with each group containing six (6) animals. Aqueous-methanolic extract of the plant was prepared and given at different doses of 200, 300 and 600mg/kg to three groups in comparison to negative and positive control groups. The aqueous-methanolic extract showed a dose-dependent increase in the activated partial thromboplastin (APTT) and prothrombin time (PT), bleeding time (BT) and clotting time (CT) (p<0.05). Warfarin 2mg/kg was used as the standard. The plant extract also showed significant (p<0.05) clot lysis in comparison with standard urokinase. Moreover, it also prolonged the ADP induced platelet adhesion at doses of 200, 300 and 600µg/mL dependently. HPLC analysis showed rutin, quercetin, salicylic acid and ascorbic acid as vital phytoconstituents in aqueous-methanolic extract. Anticoagulant and thrombolytic effect of Jasminum sambac justified its therapeutic utility in cardiovascular disorders and this may be due to the presence of salicylic acid, rutin and quercetin in the extract.

Subjects

JASMINE; SALICYLIC acid; PLANT extracts; VITAMIN C; UROKINASE

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, p1747

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.SP.1747-1754.1