Results
Title

Evaluation of cardio protective, anti-inflammatory, analgesic and CNS depressant activity of Grewia asiatica L. fruit extract.

Authors

Shahwani, Nisar Ahmad; Khan, Haroon; Muhammad, Shafi; Jan, Syed Umer; ul Haq, Noman; Jabbar, Abdul; Bano, Tahira; Qadir, Abdul; Razaque, Ghulam; Khan, Nagina Soomer; Younis, Muhammad

Abstract

Grewia asiatica L. is a potential medicinal plant used for various diseases in traditional medicine. Current study was aimed to evaluate the cardio protective, anti-inflammatory, analgesic and CNS depressant activities of Grewia asiatica L. fruit extract. In cardio protective activity myocardial injury was produced by injection of Isoproterenol (200 mg/kg, s.c), G. asiatica 250 and 500mg/kg treated groups significantly (p<0.05) decreased the level of serum AST, ALT, LDH and CKMB, hence produced cardio protective effect. In analgesic activities G. asiatica produced significant (p<0.05) analgesic effects in acetic acid induced writhing, formalin, paw pressure and tail immersion test. G. asiatica at 250 and 500mg/kg oral dose, significantly (p<0.05) reduced the rat paw edema in carrageen an induced rat paw edema test. G. asiatica extract also produced significant CNS depressant effects in open field, hole board and thiopental sodium induced sleeping time. Findings of the current study suggest that G. asiatica fruit extract showed potential pharmacological effects and can be utilized in alternative medicine.

Subjects

CENTRAL nervous system depressants; FRUIT extracts; MYOCARDIAL injury; ACETIC acid; ALTERNATIVE medicine

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, p1739

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.SP.1739-1746.1