Results
Title

Dry ripe fruit of Aegle marmelos as anti-ulcer agent against ethanol induced gastric mucosal injury.

Authors

Imran, Hina; Sohail, Tehmina; Atiq-ur-Rehman; Syed, Shazia

Abstract

Aegle marmelos is cost-effective valuable South Asian tree. The folklore data reported its wide range pharmacological effects. In spite of vast reported work on various parts, the dry ripe fruit extract has not yet been studied for gastric ulcers. Present study is planned to investigate its potential protective effects against ethanol-induced gastric injury in rats. In current study the gastro protective effect of ethanolic crude extract of A. marmelos dried ripe fruit at 200, 400 and 800mg/kg body weight were studied in albino rats. Ranitidine used as standard drug (50mg/kg body weight). Absolute ethanol increase the degree of ulceration (UI) in rats while a significant improvement in the level of inhibition against ulceration was observed in test and standard groups as compare to control. Pre-fed test drug exhibited a significant reduction in the sore area (UI), accelerate % age protection and increased of gastric content in dose dependence manner. Test drug at 800mg/kg dose showed marked deduction in mean UI 3.0, significant increase in protection 83% with pH 7.3 (p<0.01). Standard drug exhibited 3.25 UI, 81% protection with pH 7.1. In conclusion, it was found that dry ripe fruit of A. marmelos possesses a significant anti-ulcer effect in rats.

Subjects

BAEL (Tree); FRUIT drying; ANTIULCER drugs; ELLAGIC acid; STOMACH ulcers; ETHANOL

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1677

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.REG.1677-1682.1