Results
Title

Hepatoprotective activity of Ipomoea staphylina againsts d-glan/lps-induced acute hepatic failure in experimental rats.

Authors

Al-Haidari, Rwaida A.; Mohammed, Firdous Sayeed; Alhaddad, Aisha; Samman, Waad A.; El-Sayed, Abdelaziz AA; Abdellatif, Ahmed A. H.; Mostafa, Mahmoud A. H.

Abstract

The goal of this study was to see ethanolic extract of Ipomoea staphylina leaves could protect rats from D-GalN/LPS-induced AHF. Five groups (n=6) of male Wistar rats were created. Group I was given a normal control (1ml/kg); Group II was given D-GalN/LPS; Group III was given D-GalN/LPS silymarin (100 mg/kg; p.o. ); Group IV was given D-GalN/LPS ethanolic extract of I. staphylina (100mg/kg); and Group V was given D-GalN/LPS ethanolic extract of I. staphylina (200mg/kg). All animals in groups II-V were given D-GalN/LPS (400mg/kg; and 30g/kg) on the 15th day after being treated with silymarin or I. staphylina extract for 15 days. Blood was collected from all groups of animals 24 hours after D-GalN/LPS administration to conduct biochemical analysis. The levels of SGOT, SGPT, ALP, GGT and total bilirubin in animals pretreated with the extract were all considerably lower. In addition, the total protein content was considerably greater in the extract-treated mice. The extract led to a considerable decrease in LPO levels as well as a notable increase in SOD, CAT and GSH levels in liver tissue. The extract dramatically lowered TNF-α, IL-6, iNOS, NO and MPO levels in the liver tissue.

Subjects

LIVER failure; IPOMOEA; ELLAGIC acid; LABORATORY rats; RATS; SILYMARIN

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1663

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.REG.1663-1668.1