Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action.

Oyagbemi, Ademola Adetokunbo; Hassan, Fasilat Oluwakemi; Ajibade, Temitayo Olabisi; Ola-Davies, Olufunke Eunice; Omobowale, Temidayo Olutayo; Ajani, Olumide Samuel; Jarikre, Theophilus Aghogho; Soetan, Kehinde Olugboyega; Saba, Adebowale Benard; Adedapo, Adeolu Alex; Aro, Abimbola Obemisola; Oyeyemi, Matthew Olugbenga; Emikpe, Benjamin Obukowho; Nkadimeng, Sanah Malomile; McGaw, Lyndy Joy; Kayoka-Kabongo, Prudence Ngalula; Yakubu, Momoh Audu; Oguntibeju, Oluwafemi Omoniyi

Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100 mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while In-vivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.

ANGIOTENSIN converting enzyme; NITRIC-oxide synthases; ORAL drug administration; BLOOD pressure; MINERALOCORTICOID receptors; LISINOPRIL

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1581

1011-601X

Academic Journal

10.36721/PJPS.2022.35.6.REG.1581-1594.1