Results
Title

Formulation and evaluation of antiviral drug sofosbuvir fast dissolving tablets using natural super disintegrants.

Authors

Munir, Farakh; Aamir, Muhammad Naeem; Madni, Asadullah; Syed, Shahzada Khurram; Shirazi, Jafir Hussain; Khalid, Nayab; Sheikh, Fatima Akbar

Abstract

The main objective of this study to formulate of fast dissolving tablets of sofosbuvir, an antiviral drug used for hepatitis C virus. The direct compression method was employed for the formulation of sofosbuvir FDT and optimized for weight variation test, thickness, hardness, friability, wetting time, water absorption ratio, in-vitro disintegration test, and in-vitro dissolution studies, assay identification by using HPLC and stability studies. Master formulation of F4, Sofosbuvir showed promising results compared to others formulations and selected as the most suitable and best formulation among them. It also has better efficacy, disintegration and dissolution time. F4 was fabricated with both super disintegrants like croscarmellose sodium and sodium starch glycolate that lead to its required features. This formulation would be a good alternate for the management of viral diseases with better dissolution profile, stability and improved bioavailability for the patients.

Subjects

ANTIVIRAL agents; SOFOSBUVIR; HEPATITIS C virus; VIRUS diseases; DISEASE management

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1573

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.REG.1573-1580.1