Title: Effect of evodiamine on cell death pathways in human gastric cancer cells.
Authors: Hanni Zhang; Liping Liu; Pingxiang Li; Yunliang Guo; Keli Ge
Abstract: Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.
Subjects: STOMACH cancer; CANCER cells; CELL death; REACTIVE oxygen species; ANTINEOPLASTIC agents
Publication: Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1523
ISSN: 1011-601X
Publication type: Academic Journal
DOI: 10.36721/PJPS.2022.35.6.REG.1523-1529.1

Effect of evodiamine on cell death pathways in human gastric cancer cells.

Hanni Zhang; Liping Liu; Pingxiang Li; Yunliang Guo; Keli Ge