Results
Title

Pharmacological effects of Raphanus caudatus in inflammation and hematopoitic system: an in vitro and in vivo investigation.

Authors

Younus, Ishrat; Siddiq, Afshan; Baig, Sadia Ghousia; Mujeeb, Nimra

Abstract

The pods of Radish are known as Raphanus caudatus that belongs to the family Brassicaceae. They are commonly known as Mungra or Sungra in Pakistan, while the common English name for this species is Rat-tailed radish. This variety of radish is unique and less tested for pharmacological as well as toxicological potential. In the current research, the ethanol extract of pods was assessed for anti-inflammatory potential in vitro and in vivo. Furthermore the effect of plant on hematological parameters was also investigated. For in vitro study, luminol-enhanced chemiluminescence method was used while in vivo study was carried out via Acetic acid- induced Paw Edema Test in wistar rats. The extract of Raphanus caudatus indicated significant anti-inflammatory effects regarding in vitro assay. Administered tested doses (250mg, 500mg and 1000mg/kg) of plant extract showed significant reduction in rat's paw but highest in vivo anti-inflammatory effect was observed at the dose of 1000mg/kg. Moreover, in the case of hematological study, noticeable elevation of white blood cell count was observed at 500 and 1000 mg/kg. However the number of platelets was reduced in dose dependent manner.

Subjects

PAKISTAN; RADISHES; LEUKOCYTE count; LABORATORY rats

Publication

Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 6, p1495

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2022.35.6.REG.1495-1501.1