We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity.
- Authors
Abbasi, Muhammad Athar; Irshad, Misbah; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Ali Shah, Syed Adnan; Shahid, Muhammad
- Abstract
2-Furoyl-1-piperazine (1) was treated with a series of alkyl/aryl sulfonyl chlorides (2a-i) under benignant conditions to obtain its N-sulfonated derivatives (3a-i). These compounds were screened for their antibacterial potential against pathogenic bacteria. The low Minimum Inhibitory Concentration (MIC) values of these molecules, in comparison of ciprofloxacin, demonstrated their high antibacterial potential. Cytotoxic activities were ascertained through their hemolytic potential and mild hemolytic profiles of these compounds proved them to be promising compounds for drug designing and development.
- Subjects
ANTIBACTERIAL agents; PIPERAZINE; SULFONYL chlorides; ARYL chlorides; DOSAGE forms of drugs; DRUG design
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 2, p579
- ISSN
1011-601X
- Publication type
Academic Journal
- DOI
10.36721/PJPS.2022.35.2.REG.579-585.1