Title: N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity.
Authors: Abbasi, Muhammad Athar; Irshad, Misbah; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Ali Shah, Syed Adnan; Shahid, Muhammad
Abstract: 2-Furoyl-1-piperazine (1) was treated with a series of alkyl/aryl sulfonyl chlorides (2a-i) under benignant conditions to obtain its N-sulfonated derivatives (3a-i). These compounds were screened for their antibacterial potential against pathogenic bacteria. The low Minimum Inhibitory Concentration (MIC) values of these molecules, in comparison of ciprofloxacin, demonstrated their high antibacterial potential. Cytotoxic activities were ascertained through their hemolytic potential and mild hemolytic profiles of these compounds proved them to be promising compounds for drug designing and development.
Subjects: ANTIBACTERIAL agents; PIPERAZINE; SULFONYL chlorides; ARYL chlorides; DOSAGE forms of drugs; DRUG design
Publication: Pakistan Journal of Pharmaceutical Sciences, 2022, Vol 35, Issue 2, p579
ISSN: 1011-601X
Publication type: Academic Journal
DOI: 10.36721/PJPS.2022.35.2.REG.579-585.1

N-Sulfonated derivatives of (2-furoyl)piperazine: Promising antibacterial agents with mild cytotoxicity.

Abbasi, Muhammad Athar; Irshad, Misbah; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Ali Shah, Syed Adnan; Shahid, Muhammad