Results
Title

Comparison of the antidepressant like activity of homeopathic remedies (Argentum nitricum, Staphysagria and Ignatia amara) and their effect on the behavior of rodents.

Authors

Anser, Humaira; Ikram, Rahila; Khatoon, Humera; Naeem, Sadaf; Khan, Saira Saeed; Nazim, Urooj; Imam, Shahlla; Shafiq, Yusra; Ishaque, Sumaira

Abstract

The majority of the world population suffers from mental and behavioral disorder. It is the need of the time to find an alternate of presently available medicines in order to decrease the medical expense. Homeopathic remedies are available and prescribed by homeopaths for treatment of anxiety and depression. Unfortunately, no data are available that proves its potential to relieve mental illness. The current study is designed to assess neuro behavioral and antidepressant like effects of homeopathic remedies Staphysagria, Argentum nitricum and Ignatia amara in comparison with standard drug (escitalopram). Different neuro behavioral activities were analyzed. The animals were administered the doses of all homeopathic remedied (60 µl to the rats) and escitalopram (0.042 mg to rats) through the oral route. The activities were observed on day 30th and day 60th. Our result suggests that the swimming time in Staphysagria treated group were significantly improved (pth and significance rise was observed (pth day as compared to 30th day. The central square crossings were improved highly significantly (pth day dosing, by all three remedies and peripheral squares crossing were found highly significantly increased (p<0.001) after chronic dosing in Staphysagria and Ignatia amara treated groups. It is concluded from the results that all three homeopathic remedies produce comparable effects like standard drug while among all three remedies Staphysagria possess a potent antidepressant activity. To the best of our knowledge the current study reports first time the anti-depressant potential of homeopathic remedies in rodents.

Subjects

ANTIDEPRESSANTS; RODENTS; DRUG standards; ANXIETY treatment; MEDICAL care costs

Publication

Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 3, p937

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2020.33.3.REG.937-945.1