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- Title
Dose-dependent effect of aqueous extract from Dendrobium officinale on blood lipids and lipid peroxidation in hyperlipidemic rats.
- Authors
Ming Zhao; Jungang Han
- Abstract
Dendrobium officinale is a traditional Chinese herbal medicine exhibiting multiple bioactivities, showing antitumor and immune-enhancing effects. The purpose of the study is to explore the effect of aqueous extract from Dendrobium officinale on blood lipids and lipid peroxidation in hyperlipidemic rats. Hyperlipidemic rats were prepared and daily given an intragastric administration of Dendrobium officinale at doses of 0.25g/kg, 0.5g/kg, or 1g/kg, or an intragastric administration of 8mg/kg simvastatin. We determined increased serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT), aspartate transaminase (AST), reduced serum levels of HDL-C, elevated MDA levels, decreased activity of GSH-Px, SOD and CAT in liver tissues of hyperlipidemic rats. Intragastric administration of Dendrobium officinale reduced serum levels of TC, TG, LDL-C, ALT, AST, increased serum levels of HDL-C, reduced MDA levels, and enhanced activity of GSH-Px, SOD and CAT in liver tissues of hyperlipidemic rats in a dose-dependent manner. Taken together, aqueous extract from Dendrobium officinale plays an inhibitory role in the formation of high blood lipid and strengthens the antioxidant capacity in hyperlipidemic rats.
- Subjects
BLOOD lipids; DENDROBIUM; ASPARTATE aminotransferase; PEROXIDATION; CHINESE medicine
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 3, p929
- ISSN
1011-601X
- Publication type
Academic Journal
- DOI
10.36721/PJPS.2020.33.3.REG.929-935.1