Title: In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones.
Authors: Arshia; Abbasi, Sanaullah; Rasheed, Saima; Khan, Jalaluddin AJ; Saad, Syed Muhammad; Khan, Khalid Mohammed; Choudhary, M. Iqbal
Abstract: Fifteen benzophenone thiosemicarbazones were synthesized and their in vitro antiglycation activity was evaluated. The most active compound 2 (IC50 = 118.15±2.41µM) showed two folds potent activity than the standard, rutin (IC50 = 294.5±1.5µM). Compounds 1 and 3-7 showed good to moderate antiglycation activity in the range of 204.14 - 488.54µM. These compounds were also evaluated for antioxidant activity. Their structure-activity relationships have been developed. The results reveal the potential of these compounds as leads for further studies towards the development of antidiabetic drugs.
Subjects: STRUCTURE-activity relationships; THIOSEMICARBAZONES; DRUG development; ANTIOXIDANTS
Publication: Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 3, p1147
ISSN: 1011-601X
Publication type: Academic Journal
DOI: 10.36721/PJPS.2020.33.3.REG.1147-1153.1

In vitro antiglycation and antioxidant properties of benzophenone thiosemicarbazones.

Arshia; Abbasi, Sanaullah; Rasheed, Saima; Khan, Jalaluddin AJ; Saad, Syed Muhammad; Khan, Khalid Mohammed; Choudhary, M. Iqbal