Results
Title

Synthesis, characterization and SEM studies of novel 1-indanyl isoniazid and hydrazide Schiff base derivatives as new anti-tubercular agents.

Authors

Nazim, Urooj; Ali, Syed Imran; Ishrat, Ghazala; Hassan, Amir; Ahmed, Mansoor; Ali, Mohsin; Ali, Zaheer; Noori, Muahammad Yahya

Abstract

The aim of study was to synthesize 1-indanyl isoniazid and sixteen other hydrazide Schiff base derivatives from 1-indanone. All synthesized derivatives were screened for the inhibitory activity against Mycobacterium tuberculosis on three Mycobacterial strains ATCC H37Rv, known INH-sensitive (INH-S) and INH-resistant strains (INH-R) by proportion method. The derivatives were characterized using different spectroscopic techniques such as UV-Visible, FTIR, ¹H NMR, and HREIMS. In addition, to gain more insight into morphology of the structures, Scanning electron microscopy (SEM) was also performed. The results revealed that 1-indanyl isoniazid derivative (UN-1) exhibited more potent and high anti-mycobacterial activity against both INH-sensitive and INH-resistant strains of Mycobacterium tuberculosis when compared to standard anti-tubercular drug isoniazid which might be a novel isoniazid derivative as a new anti-tubercular agent.

Subjects

SCHIFF base derivatives; ISONIAZID; MYCOBACTERIUM tuberculosis; RIFAMPIN; SCANNING electron microscopy

Publication

Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 3, p1095

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2020.33.3.REG.1095-1103.1