We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Disposition and pharmacokinetics of azithromycin in serum and a lung tissue of two modified-release formulations compared with an immediate-release product on the market.
- Authors
Sierra Resendiz, Alonso; Bernad Bernad, María Josefa; Sanchez Lemus, Julio Cesar; Juarez Rodríguez, Ivan; Carlin Valderrabano, Shalaiko Christian; Vargas Estrada, Dinorah
- Abstract
The aim of this study was to determine the disposition and pharmacokinetics in serum and a lung tissue homogenate in guinea pig (Cavia porcellus) of two experimental formulations of azithromycin, those were included in a modified release polymer matrix (MRF) after oral administration. The results obtained are compared with a commercial form of immediate release. 3 groups of animals were randomly formed in groups of 7 for control and 14 for each group of modified-release formulations (MRFs) were treated with a single dose of 8mg/kg of active principle. In lung tissue, comparisons of concentration of azithromycin, showed statistically significant differences between commercial product, MRF1 and MRF2. All pharmacokinetic parameters for MRF1 and MRF2 were significantly different with the exception of Cmax with respect to commercial product. The treatment of the animals with MRFs may have several benefits over treatment with azithromycin alone since could increase dosing interval for the two MRFs evaluated and reduce the frequency of application, patient stress levels and toxicological risks by accumulation of the active principle.
- Subjects
PHARMACOKINETICS; ANIMAL welfare; COMMERCIAL products; LUNGS; GUINEA pigs
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 3, p1079
- ISSN
1011-601X
- Publication type
Academic Journal
- DOI
10.36721/PJPS.2020.33.3.REG.1079-1085.1