Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives.

Aziz-ur-Rehman; Khan, Samreen Gul; Bokhari, Tanveer Hussain; Anjum, Fozia; Akhter, Naheed; Rasool, Shahid; Shah, Syed Adnan Ali; Shahid, Muhammad; Arshad, Aneesa

A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52±0.31. Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed as reference drug. In addition to low toxicity and moderately good thrombolytic activity, the synthesized compounds possessed excellent to moderate antibacterial activity, relative to ciprofloxacin. All compounds especially 7b and 7f can be consider for further clinical studies and might be helpful in synthesis of new drugs for treatment of cardiovascular diseases.

ANTIBACTERIAL agents; CARDIOVASCULAR agents; DRUG synthesis; STREPTOKINASE; CHEMICAL synthesis

Pakistan Journal of Pharmaceutical Sciences, 2020, p871

1011-601X

Academic Journal

10.36721/PJPS.2020.33.2.SUP.871-876.1