Rosa brunonii Lindely fruit as a new protective agent evaluated against Rif/INH induced toxicity in rats.

Ahmad, Ejaz; Jahangir, Muhammad; Akhtar, Zahid Mahmood; Ishtiaq, Saiqa; Mukhtar, Hamid; Haider, Hafiz Muhammad Faizan; Bukhari, Nadeem Irfan

Rosa brunonii L., a less investigated plant contains flavonoid glycosides and is used to treat stomach ailments, heart problems, and diabetes in folk. The crude extract of the plant possesses antioxidant activity. The current work was aimed to investigate the presence of phytochemicals, antioxidative stress and protective potential of chloroform extract of the Rosa brunonii L. fruits (RBFCE) against liver and kidney toxicity induced by anti-tuberculosis drugs, rifampicin/isoniazid (Rif/INH) in Wistar albino rats. Animals were divided into six groups, each comprising 6 rats and fed with a standard pelleted diet. Normal control group was given only a standard pelleted diet. The vehicle control group received 0.5% carboxymethylcellulose (CMC) aqueous solution (vehicle). Negative and positive control groups were given Rif/INH (50+50 mg/kg, p.o) and silymarin (SILM) (200 mg/kg, p.o) in 0.5% vehicle for 30 days, respectively. Extract treated groups received low and high doses of RBFCE (500 mg/kg, p.o and 1000 mg/kg, p.o respectively) in 0.5% vehicle for 30 days. At a higher dose, animals showed significantly reduced Rif/INH induced toxicity in liver and kidney tissues as indicated by the normalized serum biochemical markers and histopathological investigations. The present exploration reveals the presence of strong antioxidant phytochemical constituents, antioxidative stress and protective potential of RBFCE against Rif/INH induced hepatic and renal damage.

RATS; ELLAGIC acid; NEPHROTOXICOLOGY; LABORATORY rats; ANTITUBERCULAR agents; FLAVONOID glycosides

Pakistan Journal of Pharmaceutical Sciences, 2020, p805

1011-601X

Academic Journal

10.36721/PJPS.2020.33.2.SUP.805-814.1