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- Title
Hypolipidemic potential of sterol containing fractions of Jolyna laminarioides: A brown alga.
- Authors
Ruqqia; Sohail, Nida; Taj, Darakhshan; Sarwar, Ghulam; Sultana, Viqar; Ara, Jehan; Ehteshamul-Haque, Syed
- Abstract
Solvent fractions (n-hexane, cholorofrom, methanol) and fractions containing sterols of Jolyna laminarioides was evaluated in triton-induced and high-fat-diet induced hyperlipidemic rats. Oral administration of J. laminarioides significantly reduced the elevated level of serum total cholesterol, triglycerides and LDL-c, both in triton induced and high fat diet induced hyperlipidemic rat models with increased serum HDL-c. Chloroform: methanol fraction (2:1) and n-hexane fraction containing sterol showed promising results in reducing LDL-c. The methanol fraction showed hypolipidemic effect by increasing HDL-c (90%). The extracts and fractions of the seaweed also decreased the increased level of cardiac and hepatic marker enzymes beside lowering lipid profile. J. laminarioides exhibited high antihyperlipidemic effects both in triton induced and high fat diet induced hyperlipidemic rats.
- Subjects
BROWN algae; HIGH-fat diet; BLOOD cholesterol; FRACTIONS
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 1, p169
- ISSN
1011-601X
- Publication type
Academic Journal
- DOI
10.36721/PJPS.2020.33.1.REG.169-174.1