An index of quality in higher education is linked to school desertion. Among the factor found by Ruiz-Ramirez et al. (2014) are personal, economic, family, teaching among other factors such as gender stereotype, gangs, health, and digital divide. The pandemic that started in March 2020 highlighted the digital divide and separated humans even more among those who can access information and technology from a computer with Internet connection and those who do not have digital tools used by higher education students during the social distancing period. This systematic review article presents the state of the art of the influence of the digital divide in relation to higher education student desertion during the COVID-19 pandemic. To carry out the present investigation, a literature review was conducted through a bibliographic design of a documental type with the use of R-Studio software within the Bibliometrix interface. Furthermore, the Prisma Declaration (Urrutia & Bonfill, 2010) was used. The results show that there is a lack of interest of the research community in investigating higher education student desertion, which is affected by the digital divide. The divide can be reverted by government policies. It was concluded that it is highly important to raise research professors and education specialists' awareness to explore the areas related to inequalities in instruction in virtual environments.