The effect of DASH diet on atherogenic indices, pro-oxidantantioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

Badali, Taghi; Arefhosseini, Sara; Rooholahzadegan, Farnaz; Tutunchi, Helda; Ebrahimi-Mameghani, Mehrangiz

Background: The present clinical trial aimed to examine whether adherence to Dietary Approaches to Stop Hypertension (DASH) diet could improve lipid profile, the Pro-oxidantantioxidant balance (PAB) as well as liver function in obese adults with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty two patients with NAFLD were equally allocated into either DASH or low-calorie diet (LCD) group for 8 weeks. The primary and secondary outcomes were determined before and after the trial. Results: Forty patients completed the trial. Significant within group differences were found in dietary saturated fat, selenium, vitamins A and E as well as body weight and body mass index (BMI) and waist circumference (WC) after the intervention (P < 0.05). DASH diet showed greater significant change in systolic and diastolic blood pressure without significant differences between the groups after 8 weeks. Apart from serum high-density lipoprotein cholesterol (HDL-C) and triglyceride/HDL-C, greater reductions were found not only in serum lipids and atherogenic indices (P < 0.05) but also in serum aspartate aminotransferase (AST), AST to platelet ratio index (APRI) and lipid accumulation product (LAP) in DASH group in comparison to control group (P = 0.008, P = 0.019 and P = 0.003, respectively). Nevertheless, there was not any difference in PAB level between the groups. Furthermore, adherence to DASH diet was more effective in alleviating liver steatosis compared with usual LCD (P = 0.012). Conclusion: Adherence to DASH diet appears to be more effective in improving obesity, atherogenic and liver steatosis biomarkers but not oxidative stress (OS) than usual LCD.

ATHEROSCLEROSIS risk factors; OBESITY treatment; HDL cholesterol; TRIGLYCERIDES; STATISTICAL significance; BODY weight; FATTY liver; SATURATED fatty acids; VITAMIN E; BLOOD platelets; NON-alcoholic fatty liver disease; ANTIOXIDANTS; MANN Whitney U Test; REGRESSION analysis; OXIDATIVE stress; RISK assessment; TREATMENT effectiveness; RANDOMIZED controlled trials; T-test (Statistics); DASH diet; VITAMIN A; WAIST circumference; CHI-squared test; ANALYSIS of covariance; DESCRIPTIVE statistics; RESEARCH funding; STATISTICAL sampling; BODY mass index; PATIENT compliance; DATA analysis software; DIETARY fats; ASPARTATE aminotransferase; ADULTS

Health Promotion Perspectives, 2023, Vol 13, Issue 1, p77

2228-6497

Academic Journal

10.34172/hpp.2023.10