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Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in patients on kidney replacement therapy: observational study using the OpenSAFELY-UKRR and SRR databases.
Published in:
Clinical Kidney Journal, 2023, v. 16, n. 11, p. 2048, doi. 10.1093/ckj/sfad184
By:
- Zheng, Bang;
- Campbell, Jacqueline;
- Carr, Edward J;
- Tazare, John;
- Nab, Linda;
- Mahalingasivam, Viyaasan;
- Mehrkar, Amir;
- Santhakumaran, Shalini;
- Steenkamp, Retha;
- Loud, Fiona;
- Lyon, Susan;
- Scanlon, Miranda;
- Hulme, William J;
- Green, Amelia C A;
- Curtis, Helen J;
- Fisher, Louis;
- Parker, Edward;
- Goldacre, Ben;
- Douglas, Ian;
- Evans, Stephen
Publication type:
Article
CHALLENGES IN ESTIMATING THE EFFECTIVENESS OF 2 DOSES OF COVID-19 VACCINE BEYOND 6 MONTHS IN ENGLAND.
Published in:
American Journal of Epidemiology, 2024, v. 193, n. 1, p. 227, doi. 10.1093/aje/kwad179
By:
- Horne, Elsie M F;
- Hulme, William J;
- Keogh, Ruth H;
- Palmer, Tom M;
- Williamson, Elizabeth J;
- Parker, Edward P K;
- Walker, Venexia M;
- Knight, Rochelle;
- Wei, Yinghui;
- Taylor, Kurt;
- Fisher, Louis;
- Morley, Jessica;
- Mehrkar, Amir;
- Dillingham, Iain;
- Bacon, Sebastian;
- Goldacre, Ben;
- Sterne, Jonathan A C;
- Collaborative, for the OpenSAFELY
Publication type:
Article
Safety of direct-acting oral anticoagulant (DOAC) prescribing: OpenSAFELY-TPP analysis of 20.5 million adults’ electronic health records.
Published in:
BJGP Open, 2024, v. 8, n. 2, p. 1, doi. 10.3399/BJGPO.2023.0163
By:
- Homan, Karen;
- Seeley, Rachel;
- Fisher, Louis;
- Khatri, Sajida;
- Smith, Katie;
- Jamieson, Tony;
- Speed, Victoria;
- Roberts, Carol A;
- Mehrkar, Amir;
- Bacon, Sebastian;
- MacKenna, Brian;
- Goldacre, Ben
Publication type:
Article
Patient Characteristics Associated with Repeat Antibiotic Prescribing Pre- and during the COVID-19 Pandemic: A Retrospective Nationwide Cohort Study of >19 Million Primary Care Records Using the OpenSAFELY Platform.
Published in:
Pharmacoepidemiology (2813-0618), 2023, v. 2, n. 2, p. 168, doi. 10.3390/pharma2020016
By:
- Orlek, Alex;
- Harvey, Eleanor;
- Fisher, Louis;
- Mehrkar, Amir;
- Bacon, Seb;
- Goldacre, Ben;
- MacKenna, Brian;
- Ashiru-Oredope, Diane
Publication type:
Article
Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.
Published in:
Eurosurveillance (15607917), 2021, v. 26, n. 11, p. 10, doi. 10.2807/1560-7917.ES.2021.26.11.2100256
By:
- Grint, Daniel J.;
- Wing, Kevin;
- Williamson, Elizabeth;
- McDonald, Helen I.;
- Bhaskaran, Krishnan;
- Evans, David;
- Evans, Stephen J. W.;
- Walker, Alex J.;
- Hickman, George;
- Nightingale, Emily;
- Schultze, Anna;
- Rentsch, Christopher T.;
- Bates, Chris;
- Cockburn, Jonathan;
- Curtis, Helen J.;
- Morton, Caroline E.;
- Bacon, Sebastian;
- Davy, Simon;
- Wong, Angel Y. S.;
- Mehrkar, Amir
Publication type:
Article
Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients' records at source using OpenSAFELY.
Published in:
BMC Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12916-024-03499-5
By:
- Andrews, Colm D.;
- Mathur, Rohini;
- Massey, Jon;
- Park, Robin;
- Curtis, Helen J.;
- Hopcroft, Lisa;
- Mehrkar, Amir;
- Bacon, Seb;
- Hickman, George;
- Smith, Rebecca;
- Evans, David;
- Ward, Tom;
- Davy, Simon;
- Inglesby, Peter;
- Dillingham, Iain;
- Maude, Steven;
- O'Dwyer, Thomas;
- Butler-Cole, Ben F. C.;
- Bridges, Lucy;
- Bates, Chris
Publication type:
Article
Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study.
Published in:
BMC Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12916-024-03477-x
By:
- Lin, Liang-Yu;
- Henderson, Alasdair D.;
- Carlile, Oliver;
- Dillingham, Iain;
- Butler-Cole, Ben F. C.;
- Marks, Michael;
- Briggs, Andrew;
- Jit, Mark;
- Tomlinson, Laurie A.;
- Bates, Chris;
- Parry, John;
- Bacon, Sebastian C. J.;
- Goldacre, Ben;
- Mehrkar, Amir;
- MacKenna, Brian;
- Eggo, Rosalind M.;
- Herrett, Emily
Publication type:
Article
Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform.
Published in:
PLoS Medicine, 2024, v. 21, n. 6, p. 1, doi. 10.1371/journal.pmed.1004398
By:
- Samuel, Miriam;
- Park, Robin Y.;
- Eastwood, Sophie V.;
- Eto, Fabiola;
- Morton, Caroline E.;
- Stow, Daniel;
- Bacon, Sebastian;
- Mehrkar, Amir;
- Morley, Jessica;
- Dillingham, Iain;
- Inglesby, Peter;
- Hulme, William J.;
- Khunti, Kamlesh;
- Mathur, Rohini;
- Valabhji, Jonathan;
- MacKenna, Brian;
- Finer, Sarah
Publication type:
Article
Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform.
Published in:
Diagnostic & Prognostic Research, 2022, v. 6, n. 1, p. 1, doi. 10.1186/s41512-022-00120-2
By:
- Williamson, Elizabeth J.;
- Tazare, John;
- Bhaskaran, Krishnan;
- McDonald, Helen I.;
- Walker, Alex J.;
- Tomlinson, Laurie;
- Wing, Kevin;
- Bacon, Sebastian;
- Bates, Chris;
- Curtis, Helen J.;
- Forbes, Harriet J.;
- Minassian, Caroline;
- Morton, Caroline E.;
- Nightingale, Emily;
- Mehrkar, Amir;
- Evans, David;
- Nicholson, Brian D.;
- Leon, David A.;
- Inglesby, Peter;
- MacKenna, Brian
Publication type:
Article
Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data.
Published in:
Annals of Internal Medicine, 2023, v. 176, n. 5, p. 685, doi. 10.7326/M21-4269
By:
- Hulme, William J.;
- Williamson, Elizabeth;
- Horne, Elsie M.F.;
- Green, Amelia;
- McDonald, Helen I.;
- Walker, Alex J.;
- Curtis, Helen J.;
- Morton, Caroline E.;
- MacKenna, Brian;
- Croker, Richard;
- Mehrkar, Amir;
- Bacon, Seb;
- Evans, David;
- Inglesby, Peter;
- Davy, Simon;
- Bhaskaran, Krishnan;
- Schultze, Anna;
- Rentsch, Christopher T.;
- Tomlinson, Laurie;
- Douglas, Ian J.
Publication type:
Article
Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study.
Published in:
Journal of Hematology & Oncology, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13045-021-01185-0
By:
- Wong, Angel Y. S.;
- Tomlinson, Laurie A.;
- Brown, Jeremy P.;
- Elson, William;
- Walker, Alex J.;
- Schultze, Anna;
- Morton, Caroline E.;
- Evans, David;
- Inglesby, Peter;
- MacKenna, Brian;
- Bhaskaran, Krishnan;
- Rentsch, Christopher T.;
- Powell, Emma;
- Williamson, Elizabeth;
- Croker, Richard;
- Bacon, Seb;
- Hulme, William;
- Bates, Chris;
- Curtis, Helen J.;
- Mehrkar, Amir
Publication type:
Article
Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY.
Published in:
BMC Medicine, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12916-022-02422-0
By:
- Green, Amelia;
- Curtis, Helen;
- Hulme, William;
- Williamson, Elizabeth;
- McDonald, Helen;
- Bhaskaran, Krishnan;
- Rentsch, Christopher;
- Schultze, Anna;
- MacKenna, Brian;
- Mahalingasivam, Viyaasan;
- Tomlinson, Laurie;
- Walker, Alex;
- Fisher, Louis;
- Massey, Jon;
- Andrews, Colm;
- Hopcroft, Lisa;
- Morton, Caroline;
- Croker, Richard;
- Morley, Jessica;
- Mehrkar, Amir
Publication type:
Article
Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.85332
By:
- Lemanska, Agnieszka;
- Andrews, Colm;
- Fisher, Louis;
- Bacon, Seb;
- Frampton, Adam E.;
- Mehrkar, Amir;
- Inglesby, Peter;
- Davy, Simon;
- Roberts, Keith;
- Patalay, Praveetha;
- Goldacre, Ben;
- MacKenna, Brian;
- Walker, Alex J.
Publication type:
Article
Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through OpenSAFELY.
Published in:
eLife, 2023, p. 1, doi. 10.7554/eLife.84673
By:
- Fisher, Louis;
- Curtis, Helen J.;
- Croker, Richard;
- Wiedemann, Milan;
- Speed, Victoria;
- Wood, Christopher;
- Brown, Andrew;
- Hopcroft, Lisa E. M.;
- Higgins, Rose;
- Massey, Jon;
- Inglesby, Peter;
- Morton, Caroline E.;
- Walker, Alex J.;
- Morley, Jessica;
- Mehrkar, Amir;
- Bacon, Seb;
- Hickman, George;
- Macdonald, Orla;
- Lewis, Tom;
- Wood, Marion
Publication type:
Article
OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic.
Published in:
British Journal of General Practice, 2023, v. 73, n. 730, p. e318, doi. 10.3399/bjgp.2022.0301
By:
- Curtis, Helen J;
- MacKenna, Brian;
- Wiedemann, Milan;
- Fisher, Louis;
- Croker, Richard;
- Morton, Caroline E;
- Inglesby, Peter;
- Walker, Alex J;
- Morley, Jessica;
- Mehrkar, Amir;
- Bacon, Sebastian CJ;
- Hickman, George;
- Evans, David;
- Ward, Tom;
- Davy, Simon;
- Hulme, William J;
- Macdonald, Orla;
- Conibere, Robin;
- Lewis, Tom;
- Myers, Martin
Publication type:
Article
Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study.
Published in:
British Journal of General Practice, 2022, v. 72, n. 720, p. e456, doi. 10.3399/bjgp.2021.0689
By:
- Wong, Angel YS;
- Tomlinson, Laurie;
- Brown, Jeremy P;
- Elson, William;
- Walker, Alex J;
- Schultze, Anna;
- Morton, Caroline E;
- Evans, David;
- Inglesby, Peter;
- MacKenna, Brian;
- Bhaskaran, Krishnan;
- Rentsch, Christopher T;
- Powell, Emma;
- Williamson, Elizabeth;
- Croker, Richard;
- Bacon, Seb;
- Hulme, William;
- Bates, Chris;
- Curtis, Helen J;
- Mehrkar, Amir
Publication type:
Article
OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19.
Published in:
2022
By:
- Curtis, Helen J;
- MacKenna, Brian;
- Croker, Richard;
- Inglesby, Peter;
- Walker, Alex J;
- Morley, Jessica;
- Mehrkar, Amir;
- Morton, Caroline E;
- Bacon, Seb;
- Hickman, George;
- Bates, Chris;
- Evans, David;
- Ward, Tom;
- Cockburn, Jonathan;
- Davy, Simon;
- Bhaskaran, Krishnan;
- Schultze, Anna;
- Rentsch, Christopher T;
- Williamson, Elizabeth J;
- Hulme, William J
Publication type:
journal article
Trends and clinical characteristics of 57.9 million COVID-19 vaccine recipients: a federated analysis of patients' primary care records using OpenSAFELY.
Published in:
2022
By:
- Curtis, Helen J;
- Inglesby, Peter;
- Morton, Caroline E;
- MacKenna, Brian;
- Green, Amelia;
- Hulme, William;
- Walker, Alex J;
- Morley, Jessica;
- Mehrkar, Amir;
- Bacon, Seb;
- Hickman, George;
- Bates, Chris;
- Croker, Richard;
- Evans, David;
- Ward, Tom;
- Cockburn, Jonathan;
- Davy, Simon;
- Bhaskaran, Krishnan;
- Schultze, Anna;
- Rentsch, Christopher T
Publication type:
journal article
Clinical coding of long COVID in English primary care: a federated analysis of 58 million patient records using OpenSAFELY.
Published in:
2021
By:
- Walker, Alex J;
- MacKenna, Brian;
- Inglesby, Peter;
- Tomlinson, Laurie;
- Rentsch, Christopher T;
- Curtis, Helen J;
- Morton, Caroline E;
- Morley, Jessica;
- Mehrkar, Amir;
- Bacon, Seb;
- Hickman, George;
- Bates, Chris;
- Croker, Richard;
- Evans, David;
- Ward, Tom;
- Cockburn, Jonathan;
- Davy, Simon;
- Bhaskaran, Krishnan;
- Schultze, Anna;
- Williamson, Elizabeth J
Publication type:
journal article
OpenSAFELY: A platform for analysing electronic health records designed for reproducible research.
Published in:
Pharmacoepidemiology & Drug Safety, 2024, v. 33, n. 6, p. 1, doi. 10.1002/pds.5815
By:
- Nab, Linda;
- Schaffer, Andrea L.;
- Hulme, William;
- DeVito, Nicholas J.;
- Dillingham, Iain;
- Wiedemann, Milan;
- Andrews, Colm D.;
- Curtis, Helen;
- Fisher, Louis;
- Green, Amelia;
- Massey, Jon;
- Walters, Caroline E.;
- Higgins, Rose;
- Cunningham, Christine;
- Morley, Jessica;
- Mehrkar, Amir;
- Hart, Liam;
- Davy, Simon;
- Evans, David;
- Hickman, George
Publication type:
Article
Exploring Prior Antibiotic Exposure Characteristics for COVID-19 Hospital Admission Patients: OpenSAFELY.
Published in:
Antibiotics (2079-6382), 2024, v. 13, n. 6, p. 566, doi. 10.3390/antibiotics13060566
By:
- Yang, Ya-Ting;
- Wong, David;
- Zhong, Xiaomin;
- Fahmi, Ali;
- Ashcroft, Darren M.;
- Hand, Kieran;
- Massey, Jon;
- Mackenna, Brian;
- Mehrkar, Amir;
- Bacon, Sebastian;
- Goldacre, Ben;
- Palin, Victoria;
- van Staa, Tjeerd
Publication type:
Article
The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England.
Published in:
Antimicrobial Resistance & Infection Control, 2023, v. 12, n. 1, p. 1, doi. 10.1186/s13756-023-01280-6
By:
- Yang, Ya-Ting;
- Zhong, Xiaomin;
- Fahmi, Ali;
- Watts, Simon;
- Ashcroft, Darren M.;
- Massey, Jon;
- Fisher, Louis;
- MacKenna, Brian;
- Mehrkar, Amir;
- Bacon, Sebastian C. J.;
- Goldacre, Ben;
- Hand, Kieran;
- van Staa, Tjeerd;
- Palin, Victoria
Publication type:
Article
Association between household composition and severe COVID-19 outcomes in older people by ethnicity: an observational cohort study using the OpenSAFELY platform.
Published in:
International Journal of Epidemiology, 2022, v. 51, n. 6, p. 1745, doi. 10.1093/ije/dyac158
By:
- Wing, Kevin;
- Grint, Daniel J;
- Mathur, Rohini;
- Gibbs, Hamish P;
- Hickman, George;
- Nightingale, Emily;
- Schultze, Anna;
- Forbes, Harriet;
- Nafilyan, Vahé;
- Bhaskaran, Krishnan;
- Williamson, Elizabeth;
- House, Thomas;
- Pellis, Lorenzo;
- Herrett, Emily;
- Gautam, Nileesa;
- Curtis, Helen J;
- Rentsch, Christopher T;
- Wong, Angel Y S;
- MacKenna, Brian;
- Mehrkar, Amir
Publication type:
Article
Recording of 'COVID-19 vaccine declined': a cohort study on 57.9 million National Health Service patients' records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021.
Published in:
Eurosurveillance (15607917), 2022, v. 27, n. 33, p. 1, doi. 10.2807/1560-7917.ES.2022.27.33.2100885
By:
- Curtis, Helen J.;
- Inglesby, Peter;
- MacKenna, Brian;
- Croker, Richard;
- Hulme, William J.;
- Rentsch, Christopher T.;
- Bhaskaran, Krishnan;
- Mathur, Rohini;
- Morton, Caroline E.;
- Bacon, Sebastian C. J.;
- Smith, Rebecca M.;
- Evans, David;
- Mehrkar, Amir;
- Tomlinson, Laurie;
- Walker, Alex J.;
- Bates, Christopher;
- Hickman, George;
- Ward, Tom;
- Morley, Jessica;
- Cockburn, Jonathan
Publication type:
Article
Implementing Germ Defence digital behaviour change intervention via all primary care practices in England to reduce respiratory infections during the COVID-19 pandemic: an efficient cluster randomised controlled trial using the OpenSAFELY platform.
Published in:
Implementation Science, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13012-023-01321-z
By:
- Ainsworth, Ben;
- Horwood, Jeremy;
- Walter, Scott R.;
- Miller, Sascha;
- Chalder, Melanie;
- De Vocht, Frank;
- Denison-Day, James;
- Elwenspoek, Martha M. C.;
- Curtis, Helen J.;
- Bates, Chris;
- Mehrkar, Amir;
- Bacon, Seb;
- Goldacre, Ben;
- Walker, Alex J.;
- MacKenna, Brian;
- Inglesby, Peter;
- Morton, Caroline E.;
- Morley, Jessica;
- Hickman, George;
- Croker, Richard
Publication type:
Article
Implementing Germ Defence digital behaviour change intervention via all primary care practices in England to reduce respiratory infections during the COVID-19 pandemic: an efficient cluster randomised controlled trial using the OpenSAFELY platform.
Published in:
Implementation Science, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13012-023-01321-z
By:
- Ainsworth, Ben;
- Horwood, Jeremy;
- Walter, Scott R.;
- Miller, Sascha;
- Chalder, Melanie;
- De Vocht, Frank;
- Denison-Day, James;
- Elwenspoek, Martha M. C.;
- Curtis, Helen J.;
- Bates, Chris;
- Mehrkar, Amir;
- Bacon, Seb;
- Goldacre, Ben;
- Walker, Alex J.;
- MacKenna, Brian;
- Inglesby, Peter;
- Morton, Caroline E.;
- Morley, Jessica;
- Hickman, George;
- Croker, Richard
Publication type:
Article
Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform.
Published in:
PLoS Medicine, 2022, v. 19, n. 1, p. 1, doi. 10.1371/journal.pmed.1003871
By:
- Bhaskaran, Krishnan;
- Rentsch, Christopher T.;
- Hickman, George;
- Hulme, William J.;
- Schultze, Anna;
- Curtis, Helen J.;
- Wing, Kevin;
- Warren-Gash, Charlotte;
- Tomlinson, Laurie;
- Bates, Chris J.;
- Mathur, Rohini;
- MacKenna, Brian;
- Mahalingasivam, Viyaasan;
- Wong, Angel;
- Walker, Alex J.;
- Morton, Caroline E.;
- Grint, Daniel;
- Mehrkar, Amir;
- Eggo, Rosalind M.;
- Inglesby, Peter
Publication type:
Article
During the COVID‐19 pandemic 20 000 prostate cancer diagnoses were missed in England.
Published in:
BJU International, 2024, v. 133, n. 5, p. 587, doi. 10.1111/bju.16305
By:
- Lemanska, Agnieszka;
- Andrews, Colm;
- Fisher, Louis;
- Bacon, Seb;
- Mehrkar, Amir;
- Inglesby, Peter;
- Davy, Simon;
- Goldacre, Ben;
- MacKenna, Brian;
- Walker, Alex J.;
- Rentsch, Christopher T.;
- Curtis, Helen J.;
- Morton, Caroline E.;
- Morley, Jessica;
- Hickman, George;
- Bates, Chris;
- Croker, Richard;
- Evans, David;
- Ward, Tom;
- Cockburn, Jonathan
Publication type:
Article

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