Genomic Analysis of Novel Bacterial Species Corynebacterium ramonii ST344 Clone Strains Isolated from Human Skin Ulcer and Rescued Cats in Japan.

Shitada, Chie; Moriguchi, Mikoto; Hayashi, Hideyuki; Matsumoto, Kazutoshi; Mori, Misato; Tokuoka, Eisuke; Yahiro, Shunsuke; Gejima, Shouichirou; Horiba, Kazuhiro; Yamamoto, Takatoshi; Takahashi, Motohide; Kuroda, Makoto

Simple Summary: Corynebacterium ramonii, which is linked to zoonotic diseases, was isolated from a human ulcer (ST344) and oral cavity of a cat (ST337/ST344) in Japan. The close genetic ties between human and cat strains suggest endemicity. The number of ST344 cases may increase, warranting ongoing genomic surveillance for infection control. Some Corynebacterium strains produce toxins that are similar to those produced by Corynebacterium diphtheriae, leading to human infections that are often transmitted through zoonotic diseases. A novel species, which is formerly classified as Corynebacterium ulcerans lineage II, was recently re-evaluated and renamed "Corynebacterium ramonii sp. nov.". We isolated C. ramonii from a human skin ulcer in Japan in 2023 (KCU0303-001) and identified it as ST344 using a genomic analysis. In addition, C. ramonii KPHES-18084 (ST344) and six strains of C. ulcerans (ST337/ST1011) were isolated from the oral cavities of 7/208 rescued cats (3.4%). The human ulcer strain KCU0303-001 and the rescued cat strain KPHES-18084 were found to be ST344 and closely related clones by core-genome and pan-genome analyses, suggesting that ST344 may be endemic to both clinical and companion animals in Japan. In support of this finding, another clinical isolate of ST344 (TSU-28 strain) was reported in Japan in 2019. Although ST337 is the most common C. ulcerans infection, the second most recent clinical isolate of C. ramonii, ST344, might be increasing; therefore, further genomic surveillance is required to monitor C. ramonii and C. ulcerans infections.

DIPHTHERIA toxin; ZOONOSES; SKIN ulcers; GENOMICS; PETS

Zoonotic Diseases (2813-0227), 2024, Vol 4, Issue 4, p234

2813-0227

Academic Journal

10.3390/zoonoticdis4040020