Results
Title

mRNA COVID-19 Vaccines—Facts and Hypotheses on Fragmentation and Encapsulation.

Authors

Demongeot, Jacques; Fougère, Cécile

Abstract

Background: The adventure of the mRNA vaccine began thirty years ago in the context of influenza. This consisted in encapsulating the mRNA coding for a viral protein in a lipid particle. We show how the mRNA encoding S protein has been modified for that purpose in the context of the anti-SARS-CoV-2 vaccination. Results: by using data coming from genetic and epidemiologic databases, we show the theoretical possibility of fragmentation of this mRNA into small RNA sequences capable of inhibiting important bio-syntheses such as the production of beta-globin. Discussion: we discuss two aspects related to mRNA vaccine: (i) the plausibility of mRNA fragmentation, and (ii) the role of liposomal nanoparticles (LNPs) used in the vaccine and their impact on mRNA biodistribution. Conclusion: we insist on the need to develop lipid nanoparticles allowing personalized administration of vaccines and avoiding adverse effects due to mRNA fragmentation and inefficient biodistribution. Hence, we recommend (i) adapting the mRNA of vaccines to the least mutated virus proteins and (ii) personalizing its administration to the categories of chronic patients at risk most likely to suffer from adverse effects.

Subjects

COVID-19 vaccines; MESSENGER RNA; FETAL hemoglobin; VACCINATION complications; NON-coding RNA; GENETIC databases

Publication

Vaccines, 2023, Vol 11, Issue 1, p40

ISSN

2076-393X

Publication type

Academic Journal

DOI

10.3390/vaccines11010040