Recent Applications of PLGA in Drug Delivery Systems.

Yang, Jie; Zeng, Huiying; Luo, Yusheng; Chen, Ying; Wang, Miao; Wu, Chuanbin; Hu, Ping

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.

MEDICAL care; DRUG delivery systems; INTRINSIC viscosity; PATIENT compliance; ANTIVIRAL agents

Polymers (20734360), 2024, Vol 16, Issue 18, p2606

2073-4360

Academic Journal

10.3390/polym16182606