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- Title
Poly(Ethylene Glycol)-Poly(l-Alanine)/Hyaluronic Acid Complex as a 3D Platform for Understanding Cancer Cell Migration in the Tumor Microenvironment.
- Authors
Sim, Jooyoung; Lee, Hyun Jung; Jeong, Byeongmoon; Park, Min Hee
- Abstract
Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments.
- Subjects
CANCER cell migration; HYALURONIC acid; TUMOR microenvironment; ETHYLENE glycol; CANCER invasiveness; POLYMERSOMES; MESENCHYMAL stem cells
- Publication
Polymers (20734360), 2021, Vol 13, Issue 7, p1042
- ISSN
2073-4360
- Publication type
Academic Journal
- DOI
10.3390/polym13071042