Works matching DE "DRUG target"

Results: 5000

Pharmacotherapy for Disease Modification in Early Parkinson's Disease: How Early Should We Be?

Published in:

Journal of Parkinson's Disease, 2024, v. 14, p. S407, doi. 10.3233/JPD-230354

By:

Mahlknecht, Philipp;
Poewe, Werner

Publication type:

Article

Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2024 Update.

Published in:

Journal of Parkinson's Disease, 2024, v. 14, n. 5, p. 899, doi. 10.3233/JPD-240272

By:

McFarthing, Kevin;
Buff, Sue;
Rafaloff, Gary;
Pitzer, Kenneth;
Fiske, Brian;
Navangul, Anaya;
Beissert, Katelyn;
Pilcicka, Aleksandra;
Fuest, Rosie;
Wyse, Richard K.;
Stott, Simon R.W.

Publication type:

Article

Waiting for PARIS—A Biological Target in Search of a Drug.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 1, p. 95, doi. 10.3233/JPD-212945

By:

Wyse, Richard K.;
Stott, Simon R.W.;
Mursaleen, Leah;
Matthews, Helen;
Dawson, Valina L.;
Dawson, Ted M.

Publication type:

Article

Endoplasmic Reticulum Stress Regulators: New Drug Targets for Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, p. S219, doi. 10.3233/JPD-212673

By:

Kovaleva, Vera;
Saarma, Mart;
Björklund, Anders;
Bloem, Bastiaan R.;
Brundin, Patrik;
Federoff, Howard

Publication type:

Article

NEAT1 on the Field of Parkinson's Disease: Offense, Defense, or a Player on the Bench?

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 1, p. 123, doi. 10.3233/JPD-202374

By:

Boros, Fanni Annamária;
Vécsei, László;
Klivényi, Péter

Publication type:

Article

The need for a shared definition of the atopic dermatitis 'super responder' in the 'treat-to-target' era.

Published in:

Clinical & Experimental Dermatology, 2025, v. 50, n. 6, p. 1202, doi. 10.1093/ced/llae542

By:

Mastorino, Luca;
Mendes-Bastos, Pedro;
Ribero, Simone;
Ortoncelli, Michela

Publication type:

Article

A heterodimer of hemoglobin identifies theranostic targets on brain‐metastasizing melanoma cells.

Published in:

International Journal of Cancer, 2025, v. 157, n. 4, p. 773, doi. 10.1002/ijc.35458

By:

Chelladurai, Maharrish;
Sagi‐Assif, Orit;
Ben‐Menachem, Shlomit;
Meshel, Tsipi;
Pasmanik‐Chor, Metsada;
Izraely, Sivan;
Hoon, Dave S. B.;
Witz, Isaac P.

Publication type:

Article

Intratumoral heterogeneity of cancer driver genomic alterations in myxoid liposarcomas.

Published in:

Cancer (0008543X), 2025, v. 131, n. 12, p. 1, doi. 10.1002/cncr.35937

By:

Schmid, Adrian;
Eisenhardt, Anja E.;
Bogner, Balazs;
Runkel, Alexander;
Lausch, Ute;
Pauli, Thomas;
Antolini, Laura N.;
Boneberg, Anika;
Kiefer, Jurij;
Bronsert, Peter;
Boerries, Melanie;
Eisenhardt, Steffen U.;
Braig, David

Publication type:

Article

Inhibition of LINC01048 decreases cell proliferation and induces the apoptosis in gastric cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02994-2

By:

Huang, Jinxi;
Yuan, Weiwei;
Li, Gaofeng;
Chen, Beibei;
Wang, Lihong;
Chen, Yulong;
Huang, Hai

Publication type:

Article

Identification of prostate cancer potential therapeutic targets and virtual drug screening through combined Mendelian randomization study, Bayesian colocalization and molecular docking.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02968-4

By:

Liang, Zilong;
Hu, Conglei;
Pang, Haofeng;
Shao, Yongxiang;
Kong, Lingchen;
Cheng, Meng;
Du, Haiyang;
Feng, Tianxi;
Fan, Zudu;
Yao, Liping;
Liu, Fei

Publication type:

Article

A novel therapeutic strategy for osteosarcoma using anti-GD2 ADC and EZH2 inhibitor.

Published in:

2025

By:

Shan, Jing;
Lin, Zicheng;
Rashid, Harunor;
Huang, Peng;
Qiang, Lei;
Liu, Yihao;
Shen, Guanlu;
Li, Yuchen;
Cui, Jiaming;
Su, Zhi;
Wang, Hanbo;
Cao, Bixuan;
Zhou, Cheng;
Kayser, Veysel;
Ning, Bo

Publication type:

Letter

Research progress on NUSAP1 and its role in digestive system neoplasms.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1582361

By:

Fu, Shangui;
Zhuo, Yuting;
Yu, Tao

Publication type:

Article

Stanniocalcin-2 significantly promotes colorectal cancer progression by regulating cancer cell proliferation and invasion.

Published in:

Journal of Cancer, 2025, v. 16, n. 8, p. 2737, doi. 10.7150/jca.101892

By:

Fang Li;
Zihao Liu;
Kaibin Huang;
Shunkai Ding;
Chang Zhu;
Yuxiang Fu;
Xiao Sun;
Shipai Zhang;
Rui Zhang;
Zhipeng Jiang;
Keli Zhong;
Qijun Zheng

Publication type:

Article

Revealing Potential Therapeutic Targets in Gastric Cancer through Inflammation and Protein-Protein Interaction Hub Networks.

Published in:

Journal of Cancer, 2025, v. 16, n. 8, p. 2720, doi. 10.7150/jca.112218

By:

Wei Wu;
Guoliang Li;
Lixin Chai;
Yating Yin;
Xin Xu;
Chenlun Han;
Hongyong Liu;
Yi Cao;
Yumiao Wang;
Qunhao Guo;
Wenxuan Chen;
Peter Wang;
Zhijian Pan

Publication type:

Article

Retinoic acid metabolism related gene CYP26B1 promotes tumor stemness and tumor microenvironment remodeling in bladder cancer.

Published in:

Journal of Cancer, 2025, v. 16, n. 8, p. 2476, doi. 10.7150/jca.101406

By:

Jun Gu;
Zhen-Duo Shi;
Kun Pang;
Lin Hao;
Wei Wang;
Cong-hui Han

Publication type:

Article

High MIG-6 expression promotes tumor proliferation and metastasis of gastric cancer.

Published in:

Journal of Cancer, 2025, v. 16, n. 8, p. 2466, doi. 10.7150/jca.98431

By:

Wenqiu Zhao;
Tao Jin;
Yun Liu;
Shihe Shao;
Feilun Cui

Publication type:

Article

Cystathionine gamma‐lyase‐mediated hypoxia inducible factor 1‐alpha expression drives clear cell ovarian cancer progression.

Published in:

Journal of Pathology, 2025, v. 266, n. 3, p. 352, doi. 10.1002/path.6433

By:

EL‐Naggar, Amal M;
Li, Yuqin;
Turgu, Busra;
Ding, Yuchen;
Wei, Longyijie;
Chen, Shary Yuting;
Trigo‐Gonzalez, Genny;
Kalantari, Forouh;
Vallejos, Rodrigo;
Lynch, Branden;
Senz, Janine;
Lum, Amy;
Douglas, J Maxwell;
Salamanca, Clara;
Thornton, Shelby;
Qin, Yimei;
Parmar, Kiran;
Spencer, Sandra E;
Leung, Samuel;
Woo, Michelle M M

Publication type:

Article

HAPIR: a refined Hallmark gene set-based machine learning approach for predicting immunotherapy response in cancer patients.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-00992-9

By:

Yuan, Mengqin;
Liu, Haizhou;
Huang, Yu-e;
Hou, Fei;
Wang, Lihong;
Wang, Quan;
Jiang, Wei

Publication type:

Article

Topology-driven negative sampling enhances generalizability in protein–protein interaction prediction Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 5, p. 1, doi. 10.1093/bioinformatics/btaf148

By:

Chatterjee, Ayan;
Ravandi, Babak;
Haddadi, Parham;
Philip, Naomi H;
Abdelmessih, Mario;
Mowrey, William R;
Ricchiuto, Piero;
Liang, Yupu;
Ding, Wei;
Mobarec, Juan Carlos;
Eliassi-Rad, Tina

Publication type:

Article

Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1596737

By:

Chunxiao, Li;
Xin, Hou;
Bowen, Liu;
Bingqing, Sun;
Mengqi, Zhou;
Shuwen, Zhang;
Jingyuan, Zhang;
Jiangtao, Lin

Publication type:

Article

Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1568780

By:

Chen, Junhao;
Zhao, Junxian;
Zhang, Zhi;
Zhu, Xingcheng;
Zuo, Jieming;
Nie, Zuqing;
Fu, Yuanzhi;
Wang, Haifeng;
Tang, Mengjun;
Fu, Shi

Publication type:

Article

A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02944-y

By:

Wu, Chunyang

Publication type:

Article

基于TCGA数据库和实验验证分析肝细胞癌中PLCβ4基因的表达及临床意义.

Published in:

Cancer Research on Prevention & Treatment, 2025, v. 52, n. 6, p. 502, doi. 10.3971/j.issn.1000-8578.2025.24.1044

By:

文丽梅;
郭娅丽;
侯强;
郑董璇;
代武;
高翔;
杨建华;
胡君萍

Publication type:

Article

EZH2 knockout in mice activates STAT3 signalling via STAT3 methylation and modulates ferroptosis in pulpitis‐affected dental pulp vascular endothelial cells: A laboratory investigation.

Published in:

International Endodontic Journal, 2025, v. 58, n. 7, p. 1025, doi. 10.1111/iej.14232

By:

Zhou, Weilin;
Huang, Weili;
You, Hongjing;
Zhang, Minyi;
Ma, Yue;
Liu, Lingjie;
Lin, Mengxuan;
He, Shuqi;
Huang, Yi

Publication type:

Article

Abnormalities of lipid metabolism in the progression and treatment of depression.

Published in:

Frontiers in Psychiatry, 2025, p. 1, doi. 10.3389/fpsyt.2025.1589663

By:

Luan, Xinchi;
Wang, Xuezhe;
Shi, Ying;
Zhang, Xinyi;
Wang, Yilin;
Zhou, Miao;
Wu, Zhaoyi;
Liu, Zijiao;
Li, Xiaoxuan;
Zhang, Lihua;
Shao, Tianyi;
Chen, Ruolan;
Chu, Xianming;
Wei, Hongyun

Publication type:

Article

D-cycloserine effects on COPD and depression in a murine experimental model.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1554337

By:

Heresco-Levy, Uriel;
Haviv, Jacob;
Caine, Yehezkel G.;
Bao, Jimmy;
Huang, Tai-Yu;
Shen, Chien-Chang;
Bogot, Naama R.

Publication type:

Article

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1541871

By:

Costa, Rita;
Ferreira, Carolina;
Alves, André;
Nunes, Sara;
Reis, Flávio;
Malva, João;
Viana, Sofia

Publication type:

Article

Investigation of GPR137C as a promising novel marker for the progression of prostate cancer through G4 screen and bioinformatics analyses.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1576835

By:

Hou, Yue;
Lu, Haowen;
Chen, Saisai;
Mao, Likai;
Huang, Xuan;
Xu, Feng;
Shu, Chuanjun

Publication type:

Article

Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real‐World Data.

Published in:

Clinical Pharmacology & Therapeutics, 2025, v. 118, n. 1, p. 242, doi. 10.1002/cpt.3682

By:

Alidoost, Mohammadali;
Huang, Jeremy Y.;
Dermentzaki, Georgia;
Blazier, Anna S.;
Gaglia, Giorgio;
Hammond, Timothy R.;
Frau, Francesca;
McCorry, Mary Clare;
Ofengeim, Dimitry;
Wilson, Jennifer L.

Publication type:

Article

Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancer.

Published in:

Respiratory Research, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12931-025-03275-w

By:

Dai, Liyuan;
Huang, Liling;
Li, Lin;
Tang, Le;
Shi, Yuankai;
Han, Xiaohong

Publication type:

Article

泛素特异性蛋白酶在肝细胞癌中的作用.

Published in:

Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2025, v. 41, n. 5, p. 968, doi. 10.12449/JCH250525

By:

唐, 怡;
王, 国泰;
蒋, 雨涵

Publication type:

Article

血红素加氧酶在代谢相关脂肪性肝病中的作用及调控机制.

Published in:

Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2025, v. 41, n. 5, p. 948, doi. 10.12449/JCH250522

By:

费, 景兰;
李, 道政;
武, 俊超;
王, 雷

Publication type:

Article

CD13 as a potential theranostic target for prostate-specific membrane antigen-negative prostate cancer and first-in-human study of [<sup>18</sup>F]AlF-CD13-L1 PET/CT imaging.

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 8, p. 2826, doi. 10.1007/s00259-025-07140-2

By:

Tang, Wei;
Zhou, Ming;
Lu, Chenxi;
Qi, Lin;
Zhang, Ye;
Tang, Yongxiang;
Gao, Xiaomei;
Hu, Shuo;
Cai, Yi

Publication type:

Article

Integrative Analysis of <sup>18</sup>F-FDG PET Radiomics and mRNA Expression in Recurrent/Metastatic Oral Squamous Cell Carcinoma: A Cross-Sectional Study.

Published in:

Molecular Imaging & Biology, 2025, v. 27, n. 3, p. 421, doi. 10.1007/s11307-025-02012-5

By:

Kim, Mai;
Gu, Wenchao;
Iwakawa, Reika Kawabata-;
Kina, Shinichiro;
Nakajima, Takahito;
Higuchi, Tetsuya;
Ogawa, Masaru;
Suzuki, Keisuke;
Tsushima, Yoshito;
Yokoo, Satoshi

Publication type:

Article

Syndecan-4 promotes gastric cancer progression through activating TGF-β1 induced lipid reprogramming and contributes positive loop circuits.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02975-5

By:

Liu, Guangjie;
Jia, Ru;
Deng, Heng;
Wang, Xiaoshan

Publication type:

Article

The impact of SRRM2-AS1 in ovarian cancer: a comprehensive analysis based on pan-cancer and in vitro validation.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02933-1

By:

Lu, Jiaojiao;
Zheng, Xia;
Li, Xu

Publication type:

Article

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02915-3

By:

Li, Xinjun;
Qi, Jie;
Xu, Ren;
Xu, Shuo;
Wang, Shengpu;
Wang, Chunxiao;
Zhao, Sufen

Publication type:

Article

Single-cell transcriptomics identify a chemotherapy-resistance related cluster overexpressed CLIC3 in ovarian cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02882-9

By:

Li, Zhefeng;
Li, Jie;
Li, Yue;
Yi, Junjie;
Zhao, Xiaoting;
Yue, Wentao

Publication type:

Article

Amplified TPM1 suppresses non-small cell lung cancer cells proliferation and metastasis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02867-8

By:

Xu, Fengling;
Lv, Jiangfeng;
Qin, Shuang;
Liu, Lijuan;
Ren, Yuguo

Publication type:

Article

LMNB1 regulates breast cancer cell senescence and migration through PPAR signaling pathway.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02709-7

By:

Meng, Shaoda;
Liu, Sicheng;
Liu, Chunsheng;
Yang, Kunxian;
Lai, Minghua

Publication type:

Article

Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02825-4

By:

Yang, Qizhou;
Zhao, Tian;
Han, Yuying;
Ji, Zhengguo;
Ye, Haihong

Publication type:

Article

卵巢透明细胞癌的分子特征和药物治疗进展.

Published in:

Fudan University Journal of Medical Sciences, 2025, v. 52, n. 3, p. 450, doi. 10.3969/j.issn.1672-8467.2025.03.017

By:

谭月;
徐言;
朱芝玲

Publication type:

Article

SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02940-2

By:

Wu, Dali;
Zhong, Guanghui;
Liu, Yufeng;
Li, Cuilian;
Yan, Lingfei;
Luo, Yang;
Li, Qing;
Liu, Dawei;
Wang, Tao

Publication type:

Article

IGF1/IGF1R signaling promotes the expansion of liver CSCs and serves as a potential therapeutic target in HCC.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02890-9

By:

Tian, Qiuju;
Zhang, Qun;
Wang, Bin;
Qian, Yanzhi;
Liu, Fengchao

Publication type:

Article

The role of non-coding RNAs in the regulation of cell death pathways in melanoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02888-3

By:

Metanat, Yekta;
Sviridova, Maria;
Al-Nuaimi, Bareq N.;
Janbazi, Fateme;
Jalali, Mahtab;
Ghalamkarpour, Nogol;
Khodabandehloo, Elnaz;
Ahmadi, Ehsan

Publication type:

Article

A Soluble Expression Construct of the Isolated Catalytic Domain of Plasmodium falciparumATP4 Exhibits ATPase Activity Independent of a γ‐Phosphate Receiving Aspartate.

Published in:

Molecular Microbiology, 2025, v. 123, n. 6, p. 479, doi. 10.1111/mmi.15358

By:

Beyer, Timo;
Caliebe, Jesko;
Kähler, Lara;
Beitz, Eric

Publication type:

Article

Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis.

Published in:

PLoS Genetics, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pgen.1011713

By:

Alshareef, Nouf O.;
Melino, Vanessa J.;
Saber, Noha;
De Rosa, Annamaria;
Rey, Elodie;
Wang, Jian You;
AlBabili, Salim;
Byrt, Caitlin;
Tester, Mark A.;
Julkowska, Magdalena M.

Publication type:

Article

Functional Features of Senescent Cells and Implications for Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5390, doi. 10.3390/ijms26115390

By:

Kirichenko, Tatiana V.;
Markina, Yuliya V.;
Markin, Alexander M.;
Vasilyev, Vyacheslav S.;
Hua, Huiming;
Li, Dahong;
Woo, Anthony Yiu-Ho;
Deev, Roman V.;
Eremin, Ilya I.;
Kotenko, Konstantin V.

Publication type:

Article

Design, Synthesis, Anti-Tumor Activity and Molecular Docking Studies of Novel Triphenylphosphine-Containing Formononetin Derivatives.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5280, doi. 10.3390/ijms26115280

By:

Cui, Hongjuan;
Zhao, Yan;
Li, Wei;
Cui, Huanjie;
Han, Jiahong;
Cai, Enbo

Publication type:

Article

Sinhyotaklisan as a Potential Therapeutic for Psoriasis: Network Pharmacology and Experimental Validation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5082, doi. 10.3390/ijms26115082

By:

Ahn, Jung-Yun;
Lim, Dong-Woo;
Kim, Jin-Hee;
Park, Sung-Yun;
Park, Sun-Dong;
Lee, Ju-Hee

Publication type:

Article