Works matching DE "PROTEIN folding"

Results: 5000

Structural Biology in the AlphaFold Era: How Far Is Artificial Intelligence from Deciphering the Protein Folding Code?

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 5, p. 674, doi. 10.3390/biom15050674

By:

Balasco, Nicole;
Esposito, Luciana;
Vitagliano, Luigi

Publication type:

Article

Conserved structural topologies in RNase A-like and trypsin-like serine proteases: a sequence-based folding analysis.

Published in:

BMC Molecular & Cell Biology, 2025, v. 26, n. 1, p. 1, doi. 10.1186/s12860-025-00542-y

By:

Kabir, K. M. Ahsanul;
Takahashi, Takuya;
Kikuchi, Takeshi

Publication type:

Article

The Molecular Chaperone TCP1 Affects Carcinogenicity and Is a Potential Therapeutic Target for Acute Myeloid Leukemia.

Published in:

Pharmaceutics, 2025, v. 17, n. 5, p. 557, doi. 10.3390/pharmaceutics17050557

By:

Wu, Yong;
Tu, Guihui;
Yuan, Yuxia;
Liu, Jingwen;
Jiang, Qingna;
Liu, Yang;
Wu, Qiurong;
Wu, Lixian;
Chen, Yuanzhong

Publication type:

Article

Structural Homology Fails to Predict Secretion Efficiency in Pichia pastoris : Divergent Responses of Architecturally Similar scFvs to Multi-Parametric Genetic Engineering.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4922, doi. 10.3390/ijms26104922

By:

Wang, Ningning;
Xiao, Yang;
Liu, Xiyu;
Li, Yuanqing;
Yu, Dehua;
Guo, Jia;
Lu, Ping;
Zhang, Xiaopeng

Publication type:

Article

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 10, p. 795, doi. 10.1038/nsmb.3087

By:

Thoma, Johannes;
Burmann, Björn M;
Hiller, Sebastian;
Müller, Daniel J

Publication type:

Article

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 8, p. 929, doi. 10.1038/nsmb.2608

By:

Li, Zhuo;
Hartl, F Ulrich;
Bracher, Andreas

Publication type:

Article

A tightly regulated molecular toggle controls AAA+ disaggregase.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1338, doi. 10.1038/nsmb.2441

By:

Oguchi, Yuki;
Kummer, Eva;
Seyffer, Fabian;
Berynskyy, Mykhaylo;
Anstett, Benjamin;
Zahn, Regina;
Wade, Rebecca C;
Mogk, Axel;
Bukau, Bernd

Publication type:

Article

Visualizing transient protein-folding intermediates by tryptophan-scanning mutagenesis.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 7, p. 731, doi. 10.1038/nsmb.2322

By:

Vallée-Bélisle, Alexis;
Michnick, Stephen W

Publication type:

Article

Crystal structure of a monomeric retroviral protease solved by protein folding game players.

Published in:

2012

By:

Khatib, Firas;
DiMaio, Frank;
Cooper, Seth;
Kazmierczyk, Maciej;
Gilski, Miroslaw;
Krzywda, Szymon;
Zabranska, Helena;
Pichova, Iva;
Thompson, James;
Popovi?, Zoran;
Jaskolski, Mariusz;
Baker, David

Publication type:

Correction Notice

Restoring order.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 3, p. 267, doi. 10.1038/nsmb.2265

By:

Chen, Inês

Publication type:

Article

Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 12, p. 1323, doi. 10.1038/nsmb.2165

By:

Hong, Seung Beom;
Kim, Byeong-Won;
Lee, Kyung-Eun;
Kim, Se Woong;
Jeon, Hyesung;
Kim, Joon;
Song, Hyun Kyu

Publication type:

Article

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 4, p. 486, doi. 10.1038/nsmb.2031

By:

DiSalvo, Susanne;
Derdowski, Aaron;
Pezza, John A.;
Serio, Tricia R.

Publication type:

Article

Genetic selection designed to stabilize proteins uncovers a chaperone called Spy.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 262, doi. 10.1038/nsmb.2016

By:

Shu Quan;
Koldewey, Philipp;
Tapley, Tim;
Kirsch, Nadine;
Ruane, Karen M.;
Pfizenmaier, Jennifer;
Rong Shi;
Hofmann, Stephan;
Foit, Linda;
Ren, Guoping;
Jakob, Ursula;
Zhaohui Xu;
Cygler, Miroslaw;
Bardwell, James C. A.

Publication type:

Article

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 12, p. 1431, doi. 10.1038/nsmb.1956

By:

Gianni, Stefano;
Ivarsson, Ylva;
De Simone, Alfonso;
Travaglini-Allocatelli, Carlo;
Brunori, Maurizio;
Vendruscolo, Michele

Publication type:

Article

Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 11, p. 1352, doi. 10.1038/nsmb.1918

By:

Tao Wang;
Darwin, K. Heran;
Huilin Li

Publication type:

Article

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1175, doi. 10.1038/nsmb.1907

By:

Woo Suk Choi;
Byung-Cheon Jeong;
Yoo Jin Joo;
Myeong-Ryeol Lee;
Joon Kim;
Eck, Michael J.;
Hyun Kyu Song

Publication type:

Article

A direct role for Hsp90 in pre-RISC formation in Drosophila.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 8, p. 1024, doi. 10.1038/nsmb.1875

By:

Miyoshi, Tomohiro;
Takeuchi, Akiko;
Siomi, Haruhiko;
Siomi, Mikiko C.

Publication type:

Article

Protein refolding is required for assembly of the type three secretion needle.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 7, p. 788, doi. 10.1038/nsmb.1822

By:

Poyraz, Ömer;
Schmidt, Holger;
Seidel, Karsten;
Delissen, Friedmar;
Ader, Christian;
Tenenboim, Hezi;
Goosmann, Christian;
Laube, Britta;
Thünemann, Andreas F.;
Zychlinsky, Arturo;
Baldus, Marc;
Lange, Adam;
Griesinger, Christian;
Kolbe, Michael

Publication type:

Article

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 3, p. 313, doi. 10.1038/nsmb.1756

By:

Bhushan, Shashi;
Gartmann, Marco;
Halic, Mario;
Armache, Jean-Paul;
Jarasch, Alexander;
Mielke, Thorsten;
Berninghausen, Otto;
Wilson, Daniel N.;
Beckmann, Roland

Publication type:

Article

Crystal structure of an intramolecular chaperone mediating triple–β-helix folding.

Published in:

Nature Structural & Molecular Biology, 2010, v. 17, n. 2, p. 210, doi. 10.1038/nsmb.1746

By:

Schulz, Eike C.;
Dickmanns, Achim;
Urlaub, Henning;
Schmitt, Andreas;
Mühlenhoff, Martina;
Stummeyer, Katharina;
Schwarzer, David;
Gerardy-Schahn, Rita;
Ficner, Ralf

Publication type:

Article

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 7, p. 684, doi. 10.1038/nsmb.1610

By:

Jianmin Gao;
Bosco, Daryl A.;
Powers, Evan T.;
Kelly, Jeffery W.

Publication type:

Article

Converging concepts of protein folding in vitro and in vivo.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 574, doi. 10.1038/nsmb.1591

By:

Hartl, F. Ulrich;
Hayer-Hartl, Manajit

Publication type:

Article

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 582, doi. 10.1038/nsmb.1592

By:

Bartlett, Alice I.;
Radford, Sheena E.

Publication type:

Article

Cellular mechanisms of membrane protein folding.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 606, doi. 10.1038/nsmb.1600

By:

Skach, William R.

Publication type:

Article

Folding to function.

Published in:: Nature Structural & Molecular Biology, 2009, v. 16, n. 6, p. 573, doi. 10.1038/nsmb0609-573
Publication type:: Article

Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 5, p. 534, doi. 10.1038/nsmb.1590

By:

Kruithof, Maarten;
Chien, Fan-Tso;
Routh, Andrew;
Logie, Colin;
Rhodes, Daniela;
van Noort, John

Publication type:

Article

Tertiary interactions within the ribosomal exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 4, p. 405, doi. 10.1038/nsmb.1571

By:

Kosolapov, Andrey;
Deutsch, Carol

Publication type:

Article

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 274, doi. 10.1038/nsmb.1554

By:

Zhang, Gong;
Hubalewska, Magdalena;
Ignatova, Zoya

Publication type:

Article

The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 3, p. 318, doi. 10.1038/nsmb.1562

By:

Friel, Claire T.;
Smith, D. Alastair;
Vendruscolo, Michele;
Gsponer, Joerg;
Radford, Sheena E.

Publication type:

Article

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 2, p. 198, doi. 10.1038/nsmb.1553

By:

Banci, Lucia;
Bertini, Ivano;
Cefaro, Chiara;
Ciofi-Baffoni, Simone;
Gallo, Angelo;
Martinelli, Manuele;
Sideris, Dionisia P;
Katrakili, Nitsa;
Tokatlidis, Kostas

Publication type:

Article

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 12, p. 1309, doi. 10.1038/nsmb.1518

By:

Zhen Xu;
Page, Richard C.;
Gomes, Michelle M.;
Kohli, Ekta;
Nix, Jay C.;
Herr, Andrew B.;
Patterson, Cam;
Misra, Saurav

Publication type:

Article

Research highlights.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 10, p. 1006, doi. 10.1038/nsmb1008-1006

By:

Lall, Sabbi;
Montoya, Michelle;
Chen, Inês

Publication type:

Article

GroEL stimulates protein folding through forced unfolding.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 3, p. 303, doi. 10.1038/nsmb.1394

By:

Zong Lin;
Madan, Damian;
Rye, Hays S.

Publication type:

Article

Structures and diseases.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 2, p. 117, doi. 10.1038/nsmb0208-117

By:

Wendt, K. Ulrich;
Weiss, Manfred S.;
Cramer, Patrick;
Heinz, Dirk W.

Publication type:

Article

Research Highlights.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 12, p. 1126, doi. 10.1038/nsmb1207-1126

By:

Konforti, Boyana;
Lall, Sabbi;
Montoya, Michelle

Publication type:

Article

Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 12, p. 1157, doi. 10.1038/nsmb1345

By:

Chimon, Sandra;
Shaibat, Medhat A.;
Jones, Christopher R.;
Calero, Diana C.;
Aizezi, Buzulagu;
Ishii, Yoshitaka

Publication type:

Article

The redox-switch domain of Hsp33 functions as dual stress sensor.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 6, p. 556, doi. 10.1038/nsmb1244

By:

Ilbert, Marianne;
Horst, Janina;
Ahrens, Sebastian;
Winter, Jeannette;
Graf, Paul C. F.;
Lilie, Hauke;
Jakob, Ursula

Publication type:

Article

Looking ahead with structural genomics.

Published in:: 2007
Publication type:: Editorial

Research Highlights.

Published in:: Nature Structural & Molecular Biology, 2006, v. 13, n. 11, p. 956, doi. 10.1038/nsmb1106-956
Publication type:: Article

An accidental breach of a protein's natural defenses.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 4, p. 295, doi. 10.1038/nsmb0406-295

By:

Dobson, Christopher M

Publication type:

Article

Structure of a membrane-based steric chaperone in complex with its lipase substrate.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 4, p. 374, doi. 10.1038/nsmb1065

By:

Pauwels, Kris;
Lustig, Ariel;
Wyns, Lode;
Tommassen, Jan;
Savvides, Savvas N;
Van Gelder, Patrick

Publication type:

Article

The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 12, p. 1094, doi. 10.1038/nsmb1017

By:

Gang Dong;
Hutagalung, Alex H.;
Chunmei Fu;
Novick, Peter;
Reinisch, Karin M.

Publication type:

Article

Folding zones inside the ribosomal exit tunnel.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 12, p. 1123, doi. 10.1038/nsmb1021

By:

Jianli Lu;
Deutsch, Carol

Publication type:

Article

Structure and chromosomal DNA binding of the SWIRM domain.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 12, p. 1078, doi. 10.1038/nsmb1022

By:

Chengmin Qian;
Qiang Zhang;
SiDe Li;
Lei Zeng;
Walsh, Martin J.;
Ming-Ming Zhou

Publication type:

Article

Archaea: Singled out from the crowd.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 3, p. 160, doi. 10.1038/nrmicro2316

By:

van Ooij, Christiaan

Publication type:

Article

DSB proteins and bacterial pathogenicity.

Published in:

Nature Reviews Microbiology, 2009, v. 7, n. 3, p. 215, doi. 10.1038/nrmicro2087

By:

Heras, Begoña;
Shouldice, Stephen R.;
Totsika, Makrina;
Scanlon, Martin J.;
Schembri, Mark A.;
Martin, Jennifer L.

Publication type:

Article

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.

Published in:

Nature Reviews Microbiology, 2009, v. 7, n. 3, p. 206, doi. 10.1038/nrmicro2069

By:

Knowles, Timothy J.;
Scott-Tucker, Anthony;
Overduin, Michael;
Henderson, Ian R.

Publication type:

Article

Novel PATL2 variants cause female infertility with oocyte maturation defect.

Published in:

Journal of Assisted Reproduction & Genetics, 2024, v. 41, n. 8, p. 1965, doi. 10.1007/s10815-024-03150-5

By:

Hu, Hua-ying;
Zhang, Ge-han;
Deng, Wei-fen;
Wei, Tian-ying;
Feng, Zhan-ke;
Li, Cun-xi;
Li, Song jun;
Liu, Jia-en;
Tian, Ya-ping

Publication type:

Article

The Millisecond Challenge.

Published in:

Bio-IT World, 2007, v. 6, n. 4, p. 10

By:

Varmazis, Catherine

Publication type:

Article

David Shaw: No Hedging on Future of Computer Simulations.

Published in:

Bio-IT World, 2006, v. 5, n. 5, p. 32

By:

Davies, Kevin

Publication type:

Article