Works matching DE "EXTRACELLULAR signal-regulated kinases"

Results: 1852

PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1577114

By:

Li, Jing;
Jiang, Fenge;
Wang, Congcong;
Sun, Ping;
Song, Lei;
Liu, Jiannan

Publication type:

Article

Exploring nano curcumin as a potential therapeutic alternative for glioblastoma multiforme via downregulation of growth factors and induction of apoptosis.

Published in:

Journal of Research in Pharmacy, 2025, v. 29, n. 3, p. 1145, doi. 10.12991/jrespharm.1694300

By:

WIDOWATI, Wahyu;
FARIED, Ahmad;
DIKI, Diki;
RAHMAT, Deni;
SUTENDI, Annisa Firdaus;
KUSUMA, Hanna Sari Widya;
DEWI, Nindia Salsabila Mia;
ZAHIROH, Fadhilah Haifa;
PRIYANDOKO, Didik;
SURAKUSUMAH, Wahyu;
AZIS, Rizal;
HADIPRASETYO, Dhanar Septyawan;
TJOKROPRANOTO, Rita;
ONGGOWIDJAJA, Philips

Publication type:

Article

Overexpression of SIK2 Inhibits FGF2-dependent Müller Glial Reprogramming.

Published in:

Experimed, 2025, v. 15, n. 1, p. 23, doi. 10.26650/experimed.1536826

By:

Bayarslan, Asli Ugurlu;
Bugra, Kuyas

Publication type:

Article

The MEK5/ERK5 pathway promotes the activation of the Hedgehog/GLI signaling in melanoma cells.

Published in:

Cellular Oncology (2211-3428), 2025, v. 48, n. 3, p. 789, doi. 10.1007/s13402-025-01050-z

By:

Tusa, Ignazia;
Gagliardi, Sinforosa;
Menconi, Alessio;
Maresca, Luisa;
Tubita, Alessandro;
Lulli, Matteo;
Stecca, Barbara;
Rovida, Elisabetta

Publication type:

Article

Multistationarity in mass action networks with applications to ERK activation.

Published in:

Journal of Mathematical Biology, 2012, v. 65, n. 1, p. 107, doi. 10.1007/s00285-011-0453-1

By:

Conradi, Carsten;
Flockerzi, Dietrich

Publication type:

Article

Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve.

Published in:

Experimental Brain Research, 2015, v. 233, n. 4, p. 1201, doi. 10.1007/s00221-015-4203-2

By:

Terayama, Ryuji;
Yamamoto, Yuya;
Kishimoto, Noriko;
Maruhama, Kotaro;
Mizutani, Masahide;
Iida, Seiji;
Sugimoto, Tomosada

Publication type:

Article

Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K/Akt and MEK/ERK pathways.

Published in:

Basic Research in Cardiology, 2013, v. 108, n. 2, p. 1, doi. 10.1007/s00395-013-0333-5

By:

Zhang, Zheng;
Li, Shuang;
Cui, Mingliang;
Gao, Xue;
Sun, Dongdong;
Qin, Xing;
Narsinh, Kazim;
Li, Chunhong;
Jia, Hongbing;
Li, Congye;
Han, Yaling;
Wang, Haichang;
Cao, Feng

Publication type:

Article

Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy.

Published in:

Basic Research in Cardiology, 2013, v. 108, n. 2, p. 1, doi. 10.1007/s00395-012-0326-9

By:

Lu, Jing;
Bian, Zhou-Yan;
Zhang, Ran;
Zhang, Yan;
Liu, Chen;
Yan, Ling;
Zhang, Shu-Min;
Jiang, Ding-Sheng;
Wei, Xiang;
Zhu, Xue;
Chen, Manyin;
Wang, Ai-Bing;
Chen, Yingjie;
Yang, Qinglin;
Liu, Peter;
Li, Hongliang

Publication type:

Article

The prostacyclin agonist iloprost aggravates fibrosis and enhances viral replication in enteroviral myocarditis by modulation of ERK signaling and increase of iNOS expression.

Published in:

Basic Research in Cardiology, 2012, v. 107, n. 5, p. 1, doi. 10.1007/s00395-012-0287-z

By:

Gruhle, Stefan;
Sauter, Martina;
Szalay, Gudrun;
Ettischer, Nicole;
Kandolf, Reinhard;
Klingel, Karin

Publication type:

Article

Taurine promotes human mesenchymal stem cells to differentiate into osteoblast through the ERK pathway.

Published in:

Amino Acids, 2014, v. 46, n. 7, p. 1673, doi. 10.1007/s00726-014-1729-8

By:

Zhou, Chenhui;
Zhang, Xue;
Xu, Liangliang;
Wu, Tie;
Cui, Liao;
Xu, Daohua

Publication type:

Article

Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway.

Published in:

Amino Acids, 2013, v. 44, n. 3, p. 961, doi. 10.1007/s00726-012-1425-5

By:

Zhu, Xiao;
Jiang, Yi;
Shan, Peng-Fei;
Shen, Jie;
Liang, Qiu-Hua;
Cui, Rong-Rong;
Liu, Yuan;
Liu, Guan-Ying;
Wu, Shan-Shan;
Lu, Qiong;
Xie, Hui;
Liu, You-Shuo;
Yuan, Ling-Qing;
Liao, Er-Yuan

Publication type:

Article

The effects of oral taurine administration on behavior and hippocampal signal transduction in rats.

Published in:

Amino Acids, 2012, v. 43, n. 5, p. 2037, doi. 10.1007/s00726-012-1282-2

By:

Iio, Wataru;
Matsukawa, Noriko;
Tsukahara, Takamitsu;
Toyoda, Atsushi

Publication type:

Article

Taurine suppresses osteoblastic differentiation of aortic valve interstitial cells induced by beta-glycerophosphate disodium, dexamethasone and ascorbic acid via the ERK pathway.

Published in:

Amino Acids, 2012, v. 43, n. 4, p. 1697, doi. 10.1007/s00726-012-1253-7

By:

Feng, Xiang;
Li, Jian-ming;
Liao, Xiao-bo;
Hu, Ye-rong;
Shang, Bao-peng;
Zhang, Zhi-yuan;
Yuan, Ling-qing;
Xie, Hui;
Sheng, Zhi-feng;
Tang, Hao;
Zhang, Wei;
Gu, Lu;
Zhou, Xin-min

Publication type:

Article

A guide to ERK dynamics, part 2: downstream decoding.

Published in:

Biochemical Journal, 2023, v. 480, n. 23, p. 1909, doi. 10.1042/BCJ20230277

By:

Ram, Abhineet;
Murphy, Devan;
DeCuzzi, Nicholaus;
Patankar, Madhura;
Hu, Jason;
Pargett, Michael;
Albeck, John G.

Publication type:

Article

An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.

Published in:

Biochemical Journal, 2021, v. 478, n. 23, p. 4119, doi. 10.1042/BCJ20210646

By:

Brown, Helen A.;
Williams, Charles A. C.;
Houjiang Zhou;
Rios-Szwed, Diana;
Fernandez-Alonso, Rosalia;
Mansoor, Saria;
McMulkin, Liam;
Toth, Rachel;
Gourlay, Robert;
Peltier, Julien;
Dieguez-Martinez, Nora;
Trost, Matthias;
Lizcano, Jose M.;
Stavridis, Marios P.;
Findlay, Greg M.

Publication type:

Article

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy.

Published in:

Biochemical Journal, 2021, v. 478, n. 5, p. 1139, doi. 10.1042/BCJ20200628

By:

Yosef, Gal;
Hayun, Hezi;
Papo, Niv

Publication type:

Article

Extracellular signal-regulated kinase (ERK) pathway control of CD8<sup>+</sup> T cell differentiation.

Published in:

Biochemical Journal, 2021, v. 478, n. 1, p. 79, doi. 10.1042/BCJ20200661

By:

Damasio, Marcos P.;
Marchingo, Julia M.;
Spinelli, Laura;
Hukelmann, Jens L.;
Cantrell, Doreen A.;
Howden, Andrew J. M.

Publication type:

Article

Conserved roles for receptor tyrosine kinase extracellular regions in regulating receptor and pathway activity.

Published in:

Biochemical Journal, 2020, v. 477, n. 21, p. 4207, doi. 10.1042/BCJ20200702

By:

Gonzalez-Magaldi, Monica;
McCabe, Jacqueline M.;
Cartwright, Haley N.;
Ningze Sun;
Leahy, Daniel J.

Publication type:

Article

Identification and validation of an m5C-related lncRNA signature for predicting prognosis and immune response in clear cell renal cell carcinoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-01987-5

By:

Ao, Shan;
Liang, Leqi;
Peng, Lei;
Yang, Riwei;
Chen, Zugen;
Deng, Tuo

Publication type:

Article

Mitogen-activated protein kinases in innate immunity.

Published in:

Nature Reviews Immunology, 2013, v. 13, n. 9, p. 679, doi. 10.1038/nri3495

By:

Arthur, J. Simon C.;
Ley, Steven C.

Publication type:

Article

SULFORAPHANE ATTENUATES HMGB1-MEDIATED ACTIVATION OF INFLAMMATORY PATHWAYS IN THE LIVER OF DIABETIC MICE AND SUPPRESSES FERROPTOSIS.

Published in:

Genetics & Applications, 2024, p. 75

By:

Vesna, Otašević;
Ana, Stančić;
Anđelija, Gudelj;
Nevena, Savić;
Milica, Markelić;
Ksenija, Veličković;
Vesna, Martinović;
Ilijana, Grigorov

Publication type:

Article

细胞外信号调节激酶 (ERK) 在阪崎肠杆菌侵袭脑微血管内皮细胞中的作用.

Published in:

Journal of Eastern Liaoning University (Natural Science Edition), 2016, v. 23, n. 3, p. 212, doi. 10.14168/j.issn.1673-4939.2016.03.13

By:

姜瑜;
张锦辉

Publication type:

Article

Insulin secretion and α-glucosidase inhibitory effects of dicaffeoylquinic acid derivatives.

Published in:

Applied Biological Chemistry, 2022, v. 65, n. 1, p. 1, doi. 10.1186/s13765-022-00688-9

By:

Lee, Dahae;
Lee, Hak-Dong;
Kwon, Hyukjin;
Lee, Hye Lim;
Hwang, Gwi Seo;
Choi, Sungyeol;
Kim, Hyun Young;
Lee, Sanghyun;
Kang, Ki Sung

Publication type:

Article

Reduction of Hippocampal Apoptosis by Intracerebroventricular Administration of Extracellular Signal-Regulated Protein Kinase and/or p38 Inhibitors in Amyloid Beta Rat Model of Alzheimer's Disease: Involvement of Nuclear-Related Factor-2 and Nuclear Factor-κ B

Published in:

Basic & Clinical Pharmacology & Toxicology, 2013, v. 112, n. 3, p. 145, doi. 10.1111/bcpt.12000

By:

Ashabi, Ghorbangol;
Alamdary, Shabnam Zeighamy;
Ramin, Mahmoudreza;
Khodagholi, Fariba

Publication type:

Article

Regulation of CCK-induced ERK1/2 activation by PKC epsilon in rat pancreatic acinar cells.

Published in:

AIMS Molecular Science, 2017, v. 4, n. 4, p. 463, doi. 10.3934/molsci.2017.4.463

By:

Chenwei Li;
Williams, John A.

Publication type:

Article

Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells.

Published in:

Plants (2223-7747), 2024, v. 13, n. 23, p. 3385, doi. 10.3390/plants13233385

By:

Monmai, Chaiwat;
Kuk, Yong-In;
Baek, So-Hyeon

Publication type:

Article

Anti-Inflammatory Effect of Ebractenoid F, a Major Active Compound of Euphorbia ebracteolata Hayata, through Inhibition of Nuclear Factor-κB Activation.

Published in:

Plants (2223-7747), 2023, v. 12, n. 15, p. 2845, doi. 10.3390/plants12152845

By:

Chun, Jaemoo;
Mah, Sang Yeon;
Kim, Yeong Shik

Publication type:

Article

Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain.

Published in:

Plants (2223-7747), 2021, v. 10, n. 5, p. 1030, doi. 10.3390/plants10051030

By:

Okuyama, Satoshi;
Furukawa, Yoshiko;
Yoshimura, Morio;
Amakura, Yoshiaki;
Nakajima, Mitsunari;
Yoshida, Takashi

Publication type:

Article

Bioactive Phytochemicals Isolated from Akebia quinata Enhances Glucose-Stimulated Insulin Secretion by Inducing PDX-1.

Published in:

Plants (2223-7747), 2020, v. 9, n. 9, p. 1087, doi. 10.3390/plants9091087

By:

Lee, Dahae;
Lee, Jin Su;
Sezirahiga, Jurdas;
Kwon, Hak Cheol;
Jang, Dae Sik;
Kang, Ki Sung

Publication type:

Article

A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs.

Published in:

Molecular & Cellular Oncology, 2021, v. 8, n. 2, p. 1, doi. 10.1080/23723556.2020.1871172

By:

Schnoeder, Tina M.;
Perner, Florian;
Heidel, Florian H.

Publication type:

Article

Dynamic ERK signaling regulation in intestinal tumorigenesis.

Published in:

Molecular & Cellular Oncology, 2018, v. 5, n. 5, p. 1, doi. 10.1080/23723556.2018.1506684

By:

Muta, Yu;
Matsuda, Michiyuki;
Imajo, Masamichi

Publication type:

Article

MAPKs trigger antiviral immunity by directly phosphorylating a rhabdovirus nucleoprotein in plants and insect vectors.

Published in:

Plant Cell, 2022, v. 34, n. 8, p. 3110, doi. 10.1093/plcell/koac143

By:

Zhi-Hang Ding;
Qiang Gao;
Xin Tong;
Wen-Ya Xu;
Lulu Ma;
Zhen-Jia Zhang;
Ying Wang;
Xian-Bing Wang

Publication type:

Article

Oncogenic Ras downregulates mdr1b expression through generation of reactive oxygen species.

Published in:

Korean Journal of Physiology & Pharmacology, 2020, v. 24, n. 3, p. 267, doi. 10.4196/kjpp.2020.24.3.267

By:

Semo Jun;
Seok Won Kim;
Byeol Kim;
In-Youb Chang;
Seon-Joo Park

Publication type:

Article

Eupatilin downregulates phorbol 12-myristate 13-acetateinduced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells.

Published in:

Korean Journal of Physiology & Pharmacology, 2020, v. 24, n. 2, p. 157, doi. 10.4196/kjpp.2020.24.2.157

By:

Yoon-Hee Cheon;
Min Seob Kim;
Ju-Young Kim;
Dong Hyun Kim;
Seung Yoon Han;
Jae-Hoon Lee

Publication type:

Article

Inhibition of ERK1/2 by silymarin in mouse mesangial cells.

Published in:

Korean Journal of Physiology & Pharmacology, 2017, v. 21, n. 1, p. 117, doi. 10.4196/kjpp.2017.21.1.117

By:

Cha Kyung Youn;
Sung Il Cho;
Min Young Lee;
Young Jin Jeon;
Seog Ki Lee

Publication type:

Article

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways.

Published in:

Korean Journal of Physiology & Pharmacology, 2015, v. 19, n. 3, p. 219, doi. 10.4196/kjpp.2015.19.3.219

By:

Yanji Cui;
Jee-Yun Park;
Jinji Wu;
Ji Hyung Lee;
Yoon-Sil Yang;
Moon-Seok Kang;
Sung-Cherl Jung;
Joo Min Park;
Eun-Sook Yoo;
Seong-Ho Kim;
Sangmee Ahn Jo;
Kyoungho Suk;
Su-Yong Eun

Publication type:

Article

Analysis of the Baroreceptor and Vestibular Receptor Inputs in the Rostral Ventrolateral Medulla following Hypotension in Conscious Rats.

Published in:

Korean Journal of Physiology & Pharmacology, 2015, v. 19, n. 2, p. 159, doi. 10.4196/kjpp.2015.19.2.159

By:

Yan Lan;
Huan-Jun Lu;
Xian Jiang;
Li-Wei Li;
Yan-Zhao Yang;
Guang-Shi Jin;
Joo Young Park;
Min Sun Kim;
Byung Rim Park;
Yuan-Zhe Jin

Publication type:

Article

ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells.

Published in:

Korean Journal of Physiology & Pharmacology, 2015, v. 19, n. 1, p. 29, doi. 10.4196/kjpp.2015.19.1.29

By:

Yu Seok Song;
Balcos, Marie Carmel;
Hye-Young Yun;
Kwang Jin Baek;
Nyoun Soo Kwon;
Myo-Kyoung Kim;
Dong-Seok Kim

Publication type:

Article

Blockade of ERK Phosphorylation in the Nucleus Accumbens Inhibits the Expression of Cocaine-induced Behavioral Sensitization in Rats.

Published in:

Korean Journal of Physiology & Pharmacology, 2011, v. 15, n. 6, p. 389, doi. 10.4196/kjpp.2011.15.6.389

By:

Seungwoo Kim;
Joong-Keun Shin;
Hyung Shin Yoon;
Jeong-Hoon Kim

Publication type:

Article

Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps.

Published in:

Oncology Letters, 2019, v. 18, n. 1, p. 181, doi. 10.3892/ol.2019.10290

By:

Zhou, Jiawei;
Yang, Yonglin;
Gan, Tingting;
Li, Yan;
Hu, Fan;
Hao, Nannan;
Yuan, Baorui;
Chen, Yu;
Zhang, Mingshun

Publication type:

Article

Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal‑regulated kinase signaling pathway.

Published in:

Oncology Letters, 2018, v. 16, n. 4, p. 5006, doi. 10.3892/ol.2018.9267

By:

Li, Mengting;
He, Yulin;
Peng, Cheng;
Xie, Xiaofang;
Hu, Guanying

Publication type:

Article

Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8442, doi. 10.3892/ol.2018.8388

By:

Yan, Weixin;
ChEN, Shouhui;
Zhao, Yiyang;
Ye, Xiaoyu

Publication type:

Article

microRNA‑23a promotes cell growth and metastasis in gastric cancer via targeting SPRY2‑mediated ERK signaling.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8433, doi. 10.3892/ol.2018.8374

By:

Li, Yingjia;
ChEN, Hui;
She, PENgfei;
ChEN, Ti;
ChEN, Lihua;
Yuan, Jinling;
Jiang, Botao

Publication type:

Article

Benzo(a)pyrene promotes Hep‑G2 cell migration and invasion by upregulating phosphorylated extracellular signal‑regulated kinase expression.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8325, doi. 10.3892/ol.2018.8379

By:

Wang, Yadong;
Pan, TENg;
Li, Li;
Wang, Haiyu;
Zhang, Ding;
Yang, Haiyan

Publication type:

Article

Upregulation of seladin-1 and nestin expression in bone marrow mesenchymal stem cell transplantation via the ERK1/2 and PI3K/Akt signaling pathways in an Alzheimer's disease model.

Published in:

Oncology Letters, 2018, v. 15, n. 5, p. 7443, doi. 10.3892/ol.2017.7543

By:

Yu, Shi;
Hei, Yue;
Liu, Weiping

Publication type:

Article

Simultaneous stimulation with tumor necrosis factor-α and transforming growth factor-β1 induces epithelial-mesenchymal transition in colon cancer cells via the NF-κB pathway.

Published in:

Oncology Letters, 2018, v. 15, n. 5, p. 6873, doi. 10.3892/ol.2018.8230

By:

Li, Yuanfei;
Zhu, Guoqiang;
Zhai, Huihong;
Jia, Junmei;
Yang, Wenhui;
Li, Xiaoqing;
Liu, Lixin

Publication type:

Article

Fibroblast activation protein in osteosarcoma cells promotes angiogenesis via AKT and ERK signaling pathways.

Published in:

Oncology Letters, 2018, v. 15, n. 4, p. 6029, doi. 10.3892/ol.2018.8027

By:

Zeng, Chao;
Wen, Ming;
Liu, Xiaomei

Publication type:

Article

Epidermal growth factor receptor expression affects proliferation and apoptosis in non-small cell lung cancer cells via the extracellular signal-regulated kinase/microRNA 200a signaling pathway.

Published in:

Oncology Letters, 2018, v. 15, n. 4, p. 5201, doi. 10.3892/ol.2018.7961

By:

Zhou, Ping;
Hu, Jian;
Wang, Xiaoqin;
Wang, Jingyuan;
Zhang, Yong;
Wang, Cong

Publication type:

Article

TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells.

Published in:

Oncology Letters, 2018, v. 15, n. 3, p. 3971, doi. 10.3892/ol.2018.7725

By:

Zhou, Rui;
Huang, Ying;
ChENg, Boran;
Wang, Yulei;
Xiong, Bin

Publication type:

Article

Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells.

Published in:

Oncology Letters, 2018, v. 15, n. 2, p. 2147, doi. 10.3892/ol.2017.7558

By:

Qiu, Junlan;
Tao, Liang;
Wei, Qiang;
Zhang, Pingyang

Publication type:

Article