Works matching DE "POLY(ADP-ribose) polymerase"

Results: 1123

Modulating NPC1L1 to Potentiate PARP Inhibitor-Induced Ferroptosis and Immune Response in Triple-Negative Breast Cancer.

Published in:

Pharmaceutics, 2025, v. 17, n. 5, p. 554, doi. 10.3390/pharmaceutics17050554

By:

Li, Ge;
Yuan, Yuxia;
Wu, Xinhua;
Wu, Lixian

Publication type:

Article

Gut microbiome associated with PARP inhibitor efficacy in patients with ovarian cancer.

Published in:

Journal of Gynecologic Oncology, 2025, v. 36, n. 3, p. 1, doi. 10.3802/jgo.2025.36.e38

By:

Okazawa-Sakai, Mika;
Sakai, Shunsuke A.;
Ichinosuke Hyodo;
Satoshi Horasawa;
Kentaro Sawada;
Takao Fujisawa;
Yasuko Yamamoto;
Shogen Boku;
Yoh Hayasaki;
Masanori Isobe;
Daisuke Shintani;
Kosei Hasegawa;
Tomomi Egawa-Takata;
Kimihiko Ito;
Kei Ihira;
Hidemichi Watari;
Kazuhiro Takehara;
Hiroshi Yagi;
Kiyoko Kato;
Tatsuyuki Chiyoda

Publication type:

Article

Bevacizumab combined with chemotherapy could be superior to chemotherapy alone in relapsed ovarian cancer after PARPi: evidence from a multi-center propensity score-matched analysis.

Published in:

Journal of Gynecologic Oncology, 2025, v. 36, n. 3, p. 1, doi. 10.3802/jgo.2025.36.e36

By:

Lin Zhong;
Haixia Wang;
Cuirong Lei;
Dongling Zou

Publication type:

Article

Inhibition of Poly(ADP)-Ribose Polymerase as a Therapeutic Strategy for Breast Cancer.

Published in:

Oncology (08909091), 2010, v. 24, n. 1, p. 55

By:

Comen, Elizabeth A.;
Robson, Mark

Publication type:

Article

PARP Inhibitors: What We Know and What We Have Yet to Know.

Published in:

Oncology (08909091), 2010, v. 24, n. 1, p. 62

By:

Puhalla, Shannon

Publication type:

Article

Capturing a Pentacyclic Fragment‐Based Library Derived from Perophoramidine: Their Design, Synthesis and Evaluation as Anticancer Compounds by DNA Double‐Strand Breaks (DSB) and PARP‐1 Inhibition.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 63, p. 1, doi. 10.1002/chem.202202405

By:

Guha, Souvik;
Yussif El‐Deeb, Ibrahim;
Yadav, Shalini;
Das, Ranajit;
Dutta Dubey, Kshatresh;
Baruah, Mousumi;
Gremaud, Ludovic;
Sen, Subhabrata

Publication type:

Article

Vitamin C alleviates hyperglycemic stress in retinal pigment epithelial cells.

Published in:

Molecular Biology Reports, 2024, v. 51, n. 1, p. 1, doi. 10.1007/s11033-024-09595-2

By:

Alahmari, Hamid;
Liu, Chia-Chun;
Rubin, Elizabeth;
Lin, Venice Y.;
Rodriguez, Paul;
Chang, Kun-Che

Publication type:

Article

Activation of proline metabolism maintains ATP levels during cocaine-induced polyADP-ribosylation.

Published in:

Amino Acids, 2021, v. 53, n. 12, p. 1903, doi. 10.1007/s00726-021-03065-w

By:

Dash, Sabyasachi;
Dash, Chandravanu;
Pandhare, Jui

Publication type:

Article

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.

Published in:

Biochemical Journal, 2024, v. 481, n. 6, p. 437, doi. 10.1042/BCJ20230406

By:

Velagapudi, Uday Kiran;
Rouleau-Turcotte, Élise;
Billur, Ramya;
Xuwei Shao;
Patil, Manisha;
Black, Ben E.;
Pascal, John M.;
Talele, Tanaji T.

Publication type:

Article

PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability.

Published in:

Biochemical Journal, 2020, v. 477, n. 23, p. 4491, doi. 10.1042/BCJ20200525

By:

Martín-Guerrero, Sandra M.;
Casado, Pedro;
Hijazi, Maruan;
Rajeeve, Vinothini;
Plaza-Díaz, Julio;
Abadía-Molina, Francisco;
Navascués, Julio;
Cuadros, Miguel A.;
Cutillas, Pedro R.;
Martín-Oliva, David

Publication type:

Article

Nanoparticles-SIRT1 Prevents Endothelial Progenitor Cells Senescence by Modulating Nitric Oxide Expression and Reducing Poly ADP-ribose Polymerase: In vitro Study.

Published in:

Trends in Sciences, 2024, v. 21, n. 6, p. 1, doi. 10.48048/tis.2024.7519

By:

Wihastuti, Titin Andri;
Chomsy, Indah Nur;
Nurwidyaningtyas, Wiwit;
Cesa, Fibe Yulinda;
Sujuti, Hidayat;
Setiawan, Meddy;
Kumboyono, Kumboyono

Publication type:

Article

Olaparib increases chemosensitivity by upregulating miR-125a-3p in ovarian cancer cells.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02048-7

By:

Wang, Zehua;
Pu, Tao;
Miao, Weiwei;
Gao, Yi;
Gao, Jianwen;
Zhang, Xinyan

Publication type:

Article

Identification of BBC3 as a novel indicator for predicting prostate cancer development and olaparib resistance.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01373-7

By:

Ma, Junjie;
Qin, Xin;
Le, Wei;
Chen, Xi;
Wang, Xiao;
Xu, Chengdang

Publication type:

Article

Genomic scarring score predicts the response to PARP inhibitors in non-small cell lung cancer.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00777-6

By:

Tsilingiri, Katerina;
Chalari, Anna;
Christopoulou, Georgia;
Voutsina, Alexandra;
Constantoulakis, Pantelis;
Potaris, Κonstantinos;
Vamvakaris, Ioannis;
Hatzidaki, Dora;
Zachou, Georgina;
Vatsellas, Giannis;
Georgoulias, Vassilis;
Kotsakis, Athanasios;
Klinakis, Apostolos

Publication type:

Article

Prediction of homologous recombination deficiency identifies colorectal tumors sensitive to PARP inhibition.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00706-7

By:

Corti, Giorgio;
Buzo, Kristi;
Berrino, Enrico;
Miotto, Martina;
Aquilano, Maria Costanza;
Lentini, Marilena;
Bellomo, Sara Erika;
Lorenzato, Annalisa;
Bartolini, Alice;
Mauri, Gianluca;
Lazzari, Luca;
Russo, Mariangela;
Di Nicolantonio, Federica;
Siena, Salvatore;
Marsoni, Silvia;
Marchiò, Caterina;
Bardelli, Alberto;
Arena, Sabrina

Publication type:

Article

Efficacy of PARP inhibitor therapy after targeted BRAF/MEK failure in advanced melanoma.

Published in:

NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00684-w

By:

Phillipps, Jordan;
Nassief, George;
Morecroft, Renee;
Adeyelu, Tolulope;
Elliott, Andrew;
Abdulla, Farah;
Vanderwalde, Ari;
Park, Soo;
Butt, Omar;
Zhou, Alice;
Ansstas, George

Publication type:

Article

Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy.

Published in:

NPJ Precision Oncology, 2024, v. 8, p. 1, doi. 10.1038/s41698-024-00526-9

By:

Walmsley, Charlotte S.;
Jonsson, Philip;
Cheng, Michael L.;
McBride, Sean;
Kaeser, Christopher;
Vargas, Herbert Alberto;
Laudone, Vincent;
Taylor, Barry S.;
Kappagantula, Rajya;
Baez, Priscilla;
Richards, Allison L.;
Noronha, Anne Marie;
Perera, Dilmi;
Berger, Michael;
Solit, David B.;
Iacobuzio-Donahue, Christine A.;
Scher, Howard I.;
Donoghue, Mark T. A.;
Abida, Wassim;
Schram, Alison M.

Publication type:

Article

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00418-4

By:

Al-Sudani, Hussein;
Ni, Ying;
Jones, Philip;
Karakilic, Huseyin;
Cui, Lei;
Johnson, Lisa D. S.;
Rose, Peter G.;
Olawaiye, Alexander;
Edwards, Robert P.;
Uger, Robert A.;
Lin, Gloria H. Y.;
Mahdi, Haider

Publication type:

Article

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression.

Published in:

NPJ Precision Oncology, 2023, v. 7, n. 1, p. 1, doi. 10.1038/s41698-023-00411-x

By:

Lavudi, Kousalya;
Banerjee, Ananya;
Li, Na;
Yang, Yajing;
Cai, Shurui;
Bai, Xuetao;
Zhang, Xiaoli;
Li, Aidan;
Wani, Elsa;
Yang, Shyh-Ming;
Zhang, Junran;
Rai, Ganesha;
Backes, Floor;
Patnaik, Srinivas;
Guo, Peixuan;
Wang, Qi-En

Publication type:

Article

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02780-0

By:

Kurgina, Tatyana A.;
Moor, Nina A.;
Kutuzov, Mikhail M.;
Naumenko, Konstantin N.;
Ukraintsev, Alexander A.;
Lavrik, Olga I.

Publication type:

Article

Rethinking the use of germline CHEK2 mutation as a marker for PARP inhibitor sensitivity.

Published in:

JNCI Cancer Spectrum, 2024, v. 8, n. 4, p. 1, doi. 10.1093/jncics/pkae045

By:

Hayman, Thomas J

Publication type:

Article

草苁蓉多糖对氧化损伤致血管内皮细胞凋亡相关蛋白表达的影响.

Published in:

Food Research & Development, 2020, v. 41, n. 22, p. 162, doi. 10.12161/j.issn.1005-6521.2020.22.027

By:

刘莉园;
张天;
张钊;
崔香丹;
尹学哲;
全吉淑

Publication type:

Article

Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2025, v. 136, n. 5, p. 1, doi. 10.1111/bcpt.70027

By:

Guo, Mengjie;
Meng, Han;
Sun, Yi;
Zhou, Lianxin;
Hu, Tingting;
Yu, Tianyi;
Bai, Haowen;
Zhang, Yuanjiao;
Gu, Chunyan;
Yang, Ye

Publication type:

Article

Inhibition of efflux transporters by poly ADP‐ribose polymerase inhibitors.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2023, v. 133, n. 4, p. 428, doi. 10.1111/bcpt.13928

By:

Deng, Feng;
Sistonen, Johanna;
Neuvonen, Mikko;
Niemi, Mikko

Publication type:

Article

Role of Poly(ADP-Ribose) Polymerase (PARP) Enzyme in the Systemic Acquired Acclimation Induced by Light Stress in Phaseolus vulgaris L. Plants.

Published in:

Plants (2223-7747), 2022, v. 11, n. 14, p. N.PAG, doi. 10.3390/plants11141870

By:

Vitale, Luca;
Vitale, Ermenegilda;
Bianchi, Anna Rita;
De Maio, Anna;
Arena, Carmen

Publication type:

Article

Assessment of Photo-Induced Cytotoxic Activity of Cachrys sicula and Cachrys libanotis Enriched-Coumarin Extracts against Human Melanoma Cells.

Published in:

Plants (2223-7747), 2021, v. 10, n. 1, p. 123, doi. 10.3390/plants10010123

By:

Marrelli, Mariangela;
Perri, Maria Rosaria;
Amodeo, Valentina;
Giordano, Francesca;
Statti, Giancarlo A.;
Panno, Maria Luisa;
Conforti, Filomena

Publication type:

Article

Photo-Protective Mechanisms and the Role of Poly (ADP-Ribose) Polymerase Activity in a Facultative CAM Plant Exposed to Long-Term Water Deprivation.

Published in:

Plants (2223-7747), 2020, v. 9, n. 9, p. 1192, doi. 10.3390/plants9091192

By:

Vitale, Luca;
Vitale, Ermenegilda;
Costanzo, Giulia;
De Maio, Anna;
Arena, Carmen

Publication type:

Article

CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer.

Published in:

Molecular & Cellular Oncology, 2020, v. 7, n. 6, p. 1, doi. 10.1080/23723556.2020.1805256

By:

Xuan, Jiachen;
Pearson, Richard B.;
Sanij, Elaine

Publication type:

Article

Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors.

Published in:

Molecular & Cellular Oncology, 2020, v. 7, n. 4, p. 1, doi. 10.1080/23723556.2020.1760675

By:

Karakashev, Sergey;
Zhang, Rugang

Publication type:

Article

Potential targeted therapies for ovarian cancer beyond PARP inhibitors.

Published in:

European Journal of Gynaecological Oncology, 2025, v. 46, n. 3, p. 1, doi. 10.22514/ejgo.2025.030

By:

Sisman, Yagmur;
Høgdall, Dan;
Schnack, Tine Henrichsen;
Høgdall, Claus;
Høgdall, Estrid

Publication type:

Article

Clinical-genomic characteristics of homologous recombination deficiency (HRD) in breast cancer: application model for practice.

Published in:

European Journal of Medical Research, 2025, p. 1, doi. 10.1186/s40001-025-02520-8

By:

Du, Jinsui;
Zhu, Lizhe;
Duan, Chenglong;
Ma, Nan;
Zhou, Yudong;
Li, Danni;
Zhang, Jianing;
Zhang, Jiaqi;
Wang, Yalong;
Liu, Xi;
Ren, Yu;
Wang, Bin

Publication type:

Article

Novel clinical potential of poly (ADP‑ribose) polymerase inhibitors in triple‑negative breast cancer: Mechanistic insights and clinical applications (Review).

Published in:

Oncology Letters, 2025, v. 29, n. 5, p. N.PAG, doi. 10.3892/ol.2025.14961

By:

Han, Yu;
Wei, Lei

Publication type:

Article

Metastatic breast cancer with double heterozygosity for the BRCA1 and BRCA2 genes responding to olaparib: A case report.

Published in:

2024

By:

Shao, Bin;
Di, Lijun

Publication type:

Case Study

Cancer of unknown primary histologically, genetically and spatially diagnosed as left ovary‑derived cancer: A case report.

Published in:

Oncology Letters, 2023, v. 26, n. 6, p. N.PAG, doi. 10.3892/ol.2023.14109

By:

Honjoh, Harunori;
Taguchi, Ayumi;
Rokutan, Hirofumi;
Mori, Ayako;
Ando, Takahiro;
Nishijima, Akira;
Eguchi, Satoko;
Miyamoto, Yuichiro;
Sone, Kenbun;
Uchino-Mori, Mayuyo;
Osuga, Yutaka

Publication type:

Article

Transporter‑mediated drug‑drug interactions involving poly (ADP‑ribose) polymerase inhibitors (Review).

Published in:

Oncology Letters, 2023, v. 25, n. 4, p. N.PAG, doi. 10.3892/ol.2023.13747

By:

Zhao, Dehua;
Long, Xiaoqing;
Wang, Jisheng

Publication type:

Article

Downregulation of ITIH3 contributes to cisplatin-based chemotherapy resistance in ovarian carcinoma via the Bcl-2 mediated anti-apoptosis signaling pathway.

Published in:

Oncology Letters, 2023, v. 25, n. 2, p. N.PAG

By:

Liu, Yingzhao;
Shi, Lijun;
Yuan, Cunzhong;
Feng, Yan;
Li, Mengdi;
Liu, Hongmei;
Chen, Xi;
Yao, Desheng;
Wang, Qi

Publication type:

Article

Effect of the PARP inhibitor veliparib on germ cell tumor cell lines.

Published in:

Oncology Letters, 2022, v. 24, n. 5, p. N.PAG, doi. 10.3892/ol.2022.13512

By:

Schmidtova, Silvia;
Udvorkova, Natalia;
Cierna, Zuzana;
Horak, Samuel;
Kalavska, Katarina;
Chovanec, Michal;
Rojikova, Lucia;
Vulevova, Miriam;
Kucerova, Lucia;
Mego, Michal

Publication type:

Article

Cyclin D1 overexpression enhances chemosensitivity to TPF chemotherapeutic agents via the caspase-3 pathway in oral cancer.

Published in:

Oncology Letters, 2020, v. 20, n. 5, p. 1, doi. 10.3892/ol.2020.12015

By:

YONG-JIE HU;
WEN-WEN SUN;
TONG-CHAO ZHAO;
YING LIU;
DONG-WANG ZHU;
LI-ZHEN WANG;
JIANG LI;
CHEN-PING ZHANG;
ZHI-YUAN ZHANG;
LAI-PING ZHONG

Publication type:

Article

PARP inhibitors and epithelial ovarian cancer: Molecular mechanisms, clinical development and future prospective.

Published in:

Oncology Letters, 2020, v. 20, n. 4, p. N.PAG, doi. 10.3892/ol.2020.11951

By:

Loizzi, Vera;
Ranieri, Girolamo;
Laforgia, Mariarita;
Gadaleta, Cosmo Damiano;
Gargano, Giulio;
Kardhashi, Anila;
De Liso, Maria;
Naglieri, Emanuele;
Del Vecchio, Vittoria;
Cicinelli, Ettore;
Cormio, Gennaro

Publication type:

Article

XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor.

Published in:

Oncology Letters, 2014, v. 8, n. 3, p. 1222, doi. 10.3892/ol.2014.2236

By:

KAIWU XU;
XINMING SONG;
ZHIHUI CHEN;
CHANGJIANG QIN;
YULONG HE

Publication type:

Article

Long-term response to Olaparib in carcinomatous meningitis of a BRCA2 mutated ovarian cancer: A case report.

Published in:

Molecular & Clinical Oncology, 2020, v. 13, n. 1, p. 73, doi. 10.3892/mco.2020.2035

By:

Favier, Laure;
Truc, Gille;
Boidot, Romain;
Bengrine-Lefevre, Leïla

Publication type:

Article

Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10.

Published in:

ChemistryOpen, 2021, v. 10, n. 10, p. 939, doi. 10.1002/open.202100087

By:

Korn, Patricia;
Classen, Arno;
Murthy, Sudarshan;
Guareschi, Riccardo;
Maksimainen, Mirko M.;
Lippok, Barbara E.;
Galera‐Prat, Albert;
Sowa, Sven T.;
Voigt, Catharina;
Rossetti, Giulia;
Lehtiö, Lari;
Bolm, Carsten;
Lüscher, Bernhard

Publication type:

Article

The evolving role of PARP inhibitors in advanced ovarian cancer.

Published in:

Forum of Clinical Oncology, 2021, v. 12, n. 1, p. 82, doi. 10.2478/fco-2021-0002

By:

Levva, Sofia;
Skolariki, Aglaia;
Sogka, Eleni;
Bokas, Alexandros;
Assi, Avraam;
Pispirigou, Marianna K.;
Koliou, Panagiotis

Publication type:

Article

PARP Inhibitors in Metastatic Castration-Resistant Prostate Cancer: Unraveling the Therapeutic Landscape.

Published in:

Life (2075-1729), 2024, v. 14, n. 2, p. 198, doi. 10.3390/life14020198

By:

Al-Akhras, Ashaar;
Hage Chehade, Chadi;
Narang, Arshit;
Swami, Umang

Publication type:

Article

Alkannin-Induced Oxidative DNA Damage Synergizes With PARP Inhibition to Cause Cancer-Specific Cytotoxicity.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.610205

By:

Chang, Mingxin;
Wang, Hongge;
Niu, Jiajing;
Song, Yan;
Zou, Zhihua

Publication type:

Article

Thymoquinone Selectively Induces Hepatocellular Carcinoma Cell Apoptosis in Synergism With Clinical Therapeutics and Dependence of p53 Status.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.555283

By:

Jehan, Shah;
Zhong, Chen;
Li, Guangyue;
Zulqarnain Bakhtiar, Syed;
Li, Dangdang;
Sui, Guangchao

Publication type:

Article

Theaflavin Induces Apoptosis of A375 Human Melanoma Cells and Inhibits Tumor Growth in Xenograft Zebrafishes Through P53- and JNK-Related Mechanism.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01317

By:

Zhang, Lei;
Yan, Bo;
Meng, Shijie;
Zhou, Li;
Xu, Yiqiao;
Du, Wenxi;
Shan, Letian

Publication type:

Article

New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00912

By:

Yan, Shijia;
Sun, Haixia;
Bu, Xianzhang;
Wan, Guohui

Publication type:

Article

Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy.

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00170

By:

Jannetti, Stephen A.;
Zeglis, Brian M.;
Zalutsky, Michael R.;
Reiner, Thomas

Publication type:

Article

Expression of poly (ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in glioma multicellular tumour spheroid model.

Published in:

Neuropathology & Applied Neurobiology, 2000, v. 26, n. 6, p. 528, doi. 10.1046/j.0305-1846.2000.00288.x

By:

Wharton, S.B.;
McNelis, U.;
Bell, H.S.;
Whittle, I.R.

Publication type:

Article