Results
Title

Synergizing Immunotherapy and Antibody–Drug Conjugates: New Horizons in Breast Cancer Therapy.

Authors

Pinto, Antonello; Guarini, Chiara; Giampaglia, Marianna; Sanna, Valeria; Melaccio, Assunta; Lanotte, Laura; Santoro, Anna Natalizia; Pini, Francesca; Cusmai, Antonio; Giuliani, Francesco; Gadaleta-Caldarola, Gennaro; Fedele, Palma

Abstract

The advent of immunotherapy and antibody–drug conjugates (ADCs) have revolutionized breast cancer treatment, offering new hope to patients. However, challenges, such as resistance and limited efficacy in certain cases, remain. Recently, the combination of these therapies has emerged as a promising approach to address these challenges. ADCs play a crucial role by delivering cytotoxic agents directly to breast cancer cells, minimizing damage to healthy tissue and enhancing the tumor-killing effect. Concurrently, immunotherapies harness the body's immune system to recognize and eliminate cancer cells. This integration offers potential to overcome resistance mechanisms and significantly improve therapeutic outcomes. This review explores the rationale behind combining immunotherapies with ADCs, recent advances in this field, and the potential implications for breast cancer treatment.

Subjects

TREATMENT effectiveness; BREAST cancer; CANCER treatment; IMMUNE system; CANCER cells; BREAST

Publication

Pharmaceutics, 2024, Vol 16, Issue 9, p1146

ISSN

1999-4923

Publication type

Academic Journal

DOI

10.3390/pharmaceutics16091146