Results
Title

Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging.

Authors

Liu, Ying; Fang, Minglv; Tu, Xiaohui; Mo, Xueying; Zhang, Lu; Yang, Binrui; Wang, Feijie; Kim, Young-Bum; Huang, Cheng; Chen, Liang; Fan, Shengjie

Abstract

Background: Aging is a natural biological process influenced by multiple factors and is a significant contributor to various chronic diseases. Slowing down the aging process and extending health span have been pursuits of the scientific field. Methods: Examination of the effects of dietary polyphenols on hallmarks of aging such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Results: Polyphenols, abundant in nature, exhibit numerous biological activities, including antioxidant effects, free radical scavenging, neuroprotection, and anti-aging properties. These compounds are generally safe and effective in potentially slowing aging and preventing age-related disorders. Conclusions: The review encourages the development of novel therapeutic strategies using dietary polyphenols to create holistic anti-aging therapies and nutritional supplements.

Subjects

PROTEINS; NEUROPROTECTIVE agents; FOOD consumption; GENOMICS; HOMEOSTASIS; CELLULAR aging; AGING; ANTIOXIDANTS; TELOMERES; MITOCHONDRIAL pathology; POLYPHENOLS; DIETARY supplements

Publication

Nutrients, 2024, Vol 16, Issue 19, p3305

ISSN

2072-6643

Publication type

Academic Journal

DOI

10.3390/nu16193305