Capsinoids Increase Antioxidative Enzyme Activity and Prevent Obesity-Induced Cardiac Injury without Positively Modulating Body Fat Accumulation and Cardiac Oxidative Biomarkers.

Santos, Késsia Cristina Carvalho; Domingos, Lucas Furtado; Nunes, Fabiane Merigueti; Simmer, Luisa Martins; Cordeiro, Evellyn Rodrigues; Filetti, Filipe Martinuzo; Bocalini, Danilo Sales; Corrêa, Camila Renata; Lima-Leopoldo, Ana Paula; Leopoldo, André Soares

Background/Objectives: Capsinoids are potential antioxidant agents capable of reducing oxidative damage and the resulting complications triggered by obesity. Thus, this study aimed to investigate the effects of capsinoids on adiposity and biomarkers of cardiac oxidative stress in obese rats induced by a high-fat diet. Methods: Male Wistar rats were exposed to a high-fat diet for 27 consecutive weeks. After the characterization of obesity (week 19), some of the obese animals began to receive capsinoids (10 mg/kg/day) by orogastric gavage. Adiposity and comorbidities were assessed. In the heart, remodeling, injury, and biomarkers of oxidative stress were determined. Results: The treatment did not reduce obesity-induced adiposity but was efficient in reducing cholesterol levels. Capsinoid treatment did not cause a difference in heart and LV mass, despite having reduced troponin I concentrations. Furthermore, capsinoids did not reduce the increase in the advanced oxidation of protein products and carbonylated proteins caused by obesity in cardiac tissue. In addition, obese rats treated with capsinoids presented high levels of malondialdehyde and greater antioxidant enzyme activity compared to untreated obese rats. Conclusions: In conclusion, treatment with capsinoids increases antioxidative enzyme activity and prevents obesity-induced cardiac injury without positively modulating body fat accumulation and cardiac oxidative biomarkers.

BRAZIL; THERAPEUTIC use of antioxidants; OBESITY complications; RISK assessment; HEART injuries; RESEARCH funding; ADIPOSE tissues; HOT peppers; OXIDATIVE stress; DIETARY fats; ENZYMES; RATS; ANIMAL experimentation; BIOMARKERS; MALONDIALDEHYDE; DISEASE risk factors

Nutrients, 2024, Vol 16, Issue 18, p3183

2072-6643

Academic Journal

10.3390/nu16183183