Results
Title

Infant Milk Formula Enriched in Dairy Cream Brings Its Digestibility Closer to Human Milk and Supports Intestinal Health in Pre-Clinical Studies.

Authors

Kondrashina, Alina; Mamone, Gianfranco; Giblin, Linda; Lane, Jonathan A.

Abstract

Human breast milk (HBM) is the "gold standard" for infant nutrition. When breast milk is insufficient or unavailable, infant milk formula (IMF) can provide a safe and nutritious alternative. However, IMFs differ considerably from HBM in composition and health function. We compared the digestibility and potential health functions of IMF containing low cream (LC-) or high cream (HC-) with pooled HBM. After simulated infant digestion of these samples, the bioavailability of key nutrients and immunomodulatory activities were determined via cell-based in vitro assays. A Caenorhabditis elegans leaky gut model was established to investigate cream effects on gut health. Distinct differences were observed in peptide diversity and sequences released from HC-IMF compared with LC-IMF during simulated digestion (p 0.05). HC-IMF also supported intestinal recovery in C. elegans following distortion versus LC-IMF (p < 0.05). These observations suggest that cream as a lipid source in IMF may provide added nutritional and functional benefits more aligned with HBM.

Subjects

IN vitro studies; DIGESTION; RESEARCH funding; MACROPHAGES; DAIRY products; GUT microbiota; BREAST milk; DIETARY fats; DESCRIPTIVE statistics; INFANT formulas; CYTOKINES; IMMUNOMODULATORS; INTERLEUKINS

Publication

Nutrients, 2024, Vol 16, Issue 18, p3065

ISSN

2072-6643

Publication type

Academic Journal

DOI

10.3390/nu16183065