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Title

Drug Consumption and Hydration Status: Analysis of the Associations in an Elder Population.

Authors

López Oliva, Sara; Morais-Moreno, Carmen; Carretero-Krug, Alejandra; Samaniego-Vaesken, María de Lourdes; López-Sobaler, Ana M.; Partearroyo, Teresa; Puga, Ana M.

Abstract

Hydration status plays a key role in healthy ageing, and it is potentially affected by several factors, including drug consumption. However, research on this issue to date is scarce, especially in highly vulnerable groups, such as the elderly. We aimed to study the relationship linking hydration status, analysed by means of a validated questionnaire, 24 h urine analysis, body composition assessment, and drug consumption in a sample of old adults. A total of 144 elders were included in the study. Cardiovascular drug consumption was significantly associated with a lower water intake in men (β = −0.282, p = 0.029). Moreover, urinary analysis revealed that total drug intake as well as the consumption of diuretics and cardiovascular drugs were associated with poorer hydration status, whereas genito-urinary drugs were associated with an opposite effect, and these results were confirmed in terms of body composition. Hence, total drug consumption (β = −0.205), diuretic (β = −0.408), cardiovascular (β = −0.297), and genito-urinary drugs (β = 0.298) were significantly associated (p < 0.05) with total body water. The obtained results confirmed the impact of chronic treatment with certain drugs on hydration status. Nutritional interventions may be of great interest in certain population groups in order to prevent complications due to altered hydration status.

Subjects

SPAIN; CROSS-sectional method; BODY composition; SCIENTIFIC observation; QUESTIONNAIRES; FISHER exact test; MULTIPLE regression analysis; SEX distribution; DIURETICS; DESCRIPTIVE statistics; MANN Whitney U Test; AGE distribution; HYDRATION; WATER in the body; URINALYSIS; URINE collection & preservation; DATA analysis software; DEHYDRATION; CARDIOVASCULAR agents; OLD age

Publication

Nutrients, 2024, Vol 16, Issue 16, p2632

ISSN

2072-6643

Publication type

Academic Journal

DOI

10.3390/nu16162632

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