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- Title
An Integrated Strategy of UHPLC-ESI-MS/MS Combined with Bioactivity-Based Molecular Networking for Identification of Antitumoral Withanolides from <i>Athenaea fasciculata</i> (Vell.) I.M.C. Rodrigues & Stehmann.
- Authors
Marques, André Mesquita; Brito, Lavinia de Carvalho; Mendonça, Simony Carvalho; Gomes, Brendo Araujo; Camillo, Flávia da Cunha; Silva, Gustavo Werneck de Souza E; Sampaio, André Luiz Franco; Leitão, Suzana Guimarães; Figueiredo, Maria Raquel
- Abstract
Athenaea fasciculata , a Brazilian native species from the Solanaceae family, is recognized as a promising source of bioactive withanolides, particularly Aurelianolide A and B, which exhibit significant antitumoral activities. Despite its potential, research on the chemical constituents of this species remains limited. This study aimed to dereplicate extracts and partitions of A. fasciculata to streamline the discovery of bioactive withanolides.
- Publication
Molecules (Basel, Switzerland), 2024, Vol 29, Issue 18
- ISSN
1420-3049
- Publication type
Journal Article
- DOI
10.3390/molecules29184357