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Title

Preparative Biocatalytic Synthesis of α-Ketomethylselenobutyrate—A Putative Agent for Cancer Therapy.

Authors

Nikulin, Maksim V.; Drobot, Viktor V.; Shurubor, Yevgeniya I.; Švedas, Vytas K.; Krasnikov, Boris F.

Abstract

Biomedical studies of the role of organic selenium compounds indicate that the amino acid derivative of L-selenomethionine, α-ketomethylselenobutyrate (KMSB), can be considered a potential anticancer therapeutic agent. It was noted that, in addition to a direct effect on redox signaling molecules, α-ketoacid metabolites of organoselenium compounds are able to change the status of histone acetylation and suppress the activity of histone deacetylases in cancer cells. However, the wide use of KMSB in biomedical research is hindered not only by its commercial unavailability, but also by the fact that there is no detailed information in the literature on possible methods for the synthesis of this compound. This paper describes in detail the procedure for obtaining a high-purity KMSB preparation (purity ≥ 99.3%) with a yield of the target product of more than 67%. L-amino acid oxidase obtained from C. adamanteus was used as a catalyst for the conversion of L-selenomethionine to KMSB. If necessary, this method can be used as a basis both for scaling up the synthesis of KMSB and for developing cost-effective biocatalytic technologies for obtaining other highly purified drugs.

Subjects

ORGANOSELENIUM compounds; CANCER treatment; AMINO acid derivatives; HISTONE acetylation; ORGANIC compounds; AMINO acids; AMINO acid oxidase; HYDROXAMIC acids

Publication

Molecules, 2023, Vol 28, Issue 17, p6178

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules28176178

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