Structural Elucidation and Cytotoxic Activity of New Monoterpenoid Indoles from Gelsemium elegans.

Song, Da; Liang, Jia-Jun; Pu, Shi-Biao; Zhang, Pan-Pan; Peng, Yun-Lin; Liu, Xia; Feng, Ting-Ting; Pu, Xiang; Zhou, Ying; Liu, Xiong-Wei; Wei, Xin

Two new monoterpenoid indole alkaloids, gelselegandines F (1) and G (2), were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by means of spectroscopic techniques and quantum chemical calculations. The ECD calculations were conducted at the B3LYP/6-311G(d,p) level and NMR calculations were carried out using the Gauge-Including Atomic Orbitals (GIAO) method. Structurally, the two new compounds possessed rare, cage-like, monoterpenoid indole skeletons. All isolated compounds and the total alkaloids extract were tested for cytotoxicity against four different tumor cell lines. The total alkaloids extract of G. elegans exhibited significant antitumor activity with IC50 values ranging from 32.63 to 82.24 ug/mL. In order to discover anticancer leads from the active extraction, both new indole compounds (1–2) were then screened for cytotoxicity. Interestingly, compound 2 showed moderate cytotoxicity against K562 leukemia cells with an IC50 value of 57.02 uM.

MONOTERPENOIDS; INDOLE alkaloids; ATOMIC orbitals; CELL lines; ANTINEOPLASTIC agents

Molecules, 2023, Vol 28, Issue 6, p2531

1420-3049

Academic Journal

10.3390/molecules28062531