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- Title
Evaluation of Phytochemistry and Pharmacological Properties of <i>Alnus nitida</i> .
- Authors
Sajid, Moniba; Khan, Muhammad Rashid; Ijaz, Muhammad Umar; Ismail, Hammad; Bhatti, Muhammad Zeeshan; Shah, Sayed Afzal; Ali, Saima; Tareen, Muhammad Usman; Alotaibi, Saqer S; Albogami, Sarah M; Batiha, Gaber El-Saber
- Abstract
In the current study, the anti-inflammatory and analgesic potential of Alnus nitida (leaves and fruits) was evaluated in the Sprague-Dawley rat. Traditionally, A. nitida was used for the treatment of inflammatory ailments. However, A. nitida leaves and fruits have not been yet reported regarding any potential medicinal effects. Leaves/fruits of A. nitida were extracted with methanol and fractionated to attain n-hexane, chloroform, ethyl acetate and aqueous fractions. These extracts were then evaluated for in vivo analgesic and anti-inflammatory potential. For in vivo anti-inflammatory activity, carrageenan-induced paw edema assay, Freunds’ complete adjuvant-induced edema, xylene-induced ear edema and histamine-induced paw edema models were used in rats, which showed significant (p < 0.01) reduction (70−80%) in edema in comparison of inflammatory controls. On other hand, for the analgesic assessment, hot plate assay and acetic acid-induced writhing tests were used, which showed a significant (p < 0.01) rise in latency time (40−60%) as compared with pain-induced controls. These results were comparable with standard drugs in a concentration-dependent manner and no mortality or toxicity was observed during all experiments. Then, for the identification of chemical constituents gas chromatography−mass spectrometry (GC-MS) analysis was performed, which indicated the presence of neophytadiene, 3,7,11,15-Tetramethyl-2-hexadecen-1-ol, phytol and vitamin E, justifying the use of A. nitida to treat inflammatory disorders.
- Publication
Molecules (Basel, Switzerland), 2022, Vol 27, Issue 14
- ISSN
1420-3049
- Publication type
Journal Article
- DOI
10.3390/molecules27144582